Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/132906
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | 'B Part of It' School Leaver study: a repeat cross-sectional study to assess the impact of increasing coverage with meningococcal B (4CMenB) vaccine on carriage of Neisseria meningitidis |
Author: | McMillan, M. Koehler, A.P. Lawrence, A. Sullivan, T.R. Bednarz, J. MacLennan, J.M. Maiden, M.C.J. Ladhani, S.N. Ramsay, M.E. Trotter, C. Borrow, R. Finn, A. Kahler, C.M. Whelan, J. Vadivelu, K. Richmond, P.C. Marshall, H.S. |
Citation: | Journal of Infectious Diseases, 2022; 225(4):637-649 |
Publisher: | Oxford University Press |
Issue Date: | 2022 |
ISSN: | 0022-1899 1537-6613 |
Statement of Responsibility: | Mark McMillan, Ann P. Koehler, Andrew Lawrence, Thomas R. Sullivan, Jana Bednarz, Jenny M. MacLennan, Martin C. J. Maiden, Shamez N. Ladhani, Mary E. Ramsay, Caroline Trotter, Ray Borrow, Adam Finn, Charlene M. Kahler, Jane Whelan, Kumaran Vadivelu, Peter C. Richmond, and Helen S. Marshall |
Abstract: | BACKGROUND: Recombinant protein-based vaccines targeting serogroup B meningococci protect against invasive disease, but impacts on carriage are uncertain. This study assessed carriage prevalence of disease-associated meningococci from 2018-2020, as the proportion of vaccinated adolescents increased following introduction of a school-based 4CMenB immunisation program. METHODS: Eligible participants who completed high school (age 17-25) in South Australia in the previous year had an oropharyngeal swab taken and completed a risk factor questionnaire. Disease-associated meningococci (genogroups A, B, C, W, X, Y) were detected by meningococcal and genogroup-specific polymerase chain reaction. RESULTS: The final analysis included 4104 participants in 2018, 2690 in 2019, and 1338 in 2020. The proportion vaccinated with 4CMenB increased from 43% in 2018, to 78% in 2019, and 76% in 2020. Carriage prevalence of disease-associated meningococci in 2018 was 225/4104 (5.5%). There was little difference between the carriage prevalence in 2019 (134/2690, 5.0%, adjusted odds ratio [aOR] 0.82, 95% CI 0.64-1.05) and 2020 (68/1338, 5.1% aOR 0.82, 95% CI 0.57-1.17) compared to 2018. CONCLUSIONS: Increased 4CMenB uptake in adolescents was not associated with a decline in carriage of disease-associated meningococci. 4CMenB immunisation programs should focus on direct (individual) protection for groups at greatest risk of disease. |
Keywords: | 4CMenB Neisseria meningitidis carriage herd protection meningococcal |
Description: | Published online September 6, 2021 |
Rights: | © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. https://doi.org/10.1093/infdis/jiab444 |
DOI: | 10.1093/infdis/jiab444 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1155066 |
Published version: | http://dx.doi.org/10.1093/infdis/jiab444 |
Appears in Collections: | Medicine publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_132906.pdf | Accepted version | 1.08 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.