Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/132913
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dc.contributor.author | Baby, T. | - |
dc.contributor.author | Liu, Y. | - |
dc.contributor.author | Yang, G. | - |
dc.contributor.author | Chen, D. | - |
dc.contributor.author | Zhao, C.X. | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Colloid and Interface Science, 2021; 594:474-484 | - |
dc.identifier.issn | 0021-9797 | - |
dc.identifier.issn | 1095-7103 | - |
dc.identifier.uri | https://hdl.handle.net/2440/132913 | - |
dc.description.abstract | Polymer nanoparticles (NPs) have attracted significant interest in the past years for drug delivery and triggered release. However, it remains a significant challenge to produce polymer NPs with controlled properties and tunable drug loading. Traditional nanoprecipitation often leads to low drug loading. This study reports the development of a new microfluidic nanoprecipitation approach for making polymer NPs with tunable drug loading up to 50%. The synthesized curcumin-loaded shellac NPs remain very stable for the period of our experiments (10 days) under acidic conditions (pH 4.5), but release the payload at neutral pH in a sustained manner. This work provides a new strategy for making drug-loaded polymer NPs with tunable drug loading and triggered release. | - |
dc.description.statementofresponsibility | Thejus Baby, Yun Liu, Guangze Yang, Dong Chen, Chun-Xia Zhao | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2021 Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jcis.2021.03.035 | - |
dc.subject | Polymer nanoparticles; microfluidics; drug delivery; drug loading; pH triggered release | - |
dc.subject.mesh | Curcumin | - |
dc.subject.mesh | Polymers | - |
dc.subject.mesh | Pharmaceutical Preparations | - |
dc.subject.mesh | Drug Carriers | - |
dc.subject.mesh | Microfluidics | - |
dc.subject.mesh | Hydrogen-Ion Concentration | - |
dc.subject.mesh | Particle Size | - |
dc.subject.mesh | Nanoparticles | - |
dc.subject.mesh | Drug Liberation | - |
dc.title | Microfluidic synthesis of curcumin loaded polymer nanoparticles with tunable drug loading and pH-triggered release | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jcis.2021.03.035 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/FT140100726 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP200101238 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Liu, Y. [0000-0003-1320-139X] | - |
dc.identifier.orcid | Yang, G. [0000-0002-6194-1918] | - |
Appears in Collections: | Chemical Engineering publications |
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