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https://hdl.handle.net/2440/133507
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dc.contributor.author | Yu, L. | - |
dc.contributor.author | Sun, Q. | - |
dc.contributor.author | Hui, Y. | - |
dc.contributor.author | Seth, A. | - |
dc.contributor.author | Petrovsky, N. | - |
dc.contributor.author | Zhao, C.X. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of Colloid and Interface Science, 2019; 539:497-503 | - |
dc.identifier.issn | 0021-9797 | - |
dc.identifier.issn | 1095-7103 | - |
dc.identifier.uri | https://hdl.handle.net/2440/133507 | - |
dc.description.abstract | Alginate hydrogel particles are promising delivery systems for protein encapsulation and controlled release because of their excellent biocompatibility, biodegradability, and mild gelation process. In this study, a facile microfluidic approach is developed for making uniform core-shell hydrogel microparticles. To address the challenge of protein retention within the alginate gel matrix, poly(ethyleneimine) (PEI)- and chitosan-coated alginate microparticles were fabricated demonstrating improved protein retention as well as controlled release. Furthermore, a model protein ovalbumin was loaded along with delta inulin microparticulate adjuvant into the water-core of the alginate microparticles. Compared to those microparticles with only antigen loaded, the antigen + adjuvant loaded microparticles showed a delayed and sustained release of antigen. This microfluidic approach provides a convenient method for making well-controlled alginate microgel particles with uniform size and controlled properties, and demonstrates the ability to tune the release profiles of proteins by engineering microparticle structure and properties. | - |
dc.description.statementofresponsibility | Lei Yu, Qi Sun, Yue Hui, Arjun Seth, Nikolai Petrovsky, Chun-Xia Zhao | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2018 Elsevier Inc. All rights reserved | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jcis.2018.12.075 | - |
dc.subject | Alginates | - |
dc.subject | Ovalbumin | - |
dc.subject | Delayed-Action Preparations | - |
dc.subject | Microfluidic Analytical Techniques | - |
dc.subject | Microspheres | - |
dc.subject | Particle Size | - |
dc.subject | Surface Properties | - |
dc.subject | Hydrogel, Polyethylene Glycol Dimethacrylate | - |
dc.subject.mesh | Alginates | - |
dc.subject.mesh | Ovalbumin | - |
dc.subject.mesh | Delayed-Action Preparations | - |
dc.subject.mesh | Microfluidic Analytical Techniques | - |
dc.subject.mesh | Microspheres | - |
dc.subject.mesh | Particle Size | - |
dc.subject.mesh | Surface Properties | - |
dc.subject.mesh | Hydrogel, Polyethylene Glycol Dimethacrylate | - |
dc.title | Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jcis.2018.12.075 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/LP140100424 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/FT140100726 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hui, Y. [0000-0002-1057-5671] | - |
Appears in Collections: | Chemical Engineering publications |
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