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https://hdl.handle.net/2440/13398
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Type: | Journal article |
Title: | D-amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus |
Author: | Torres, A. Menz, I. Alewood, P. Bansal, P. Lahnstein, J. Gallagher, C. Kuchel, P. |
Citation: | FEBS Letters, 2002; 524(1-3):172-176 |
Publisher: | Elsevier Science BV |
Issue Date: | 2002 |
ISSN: | 0014-5793 1873-3468 |
Statement of Responsibility: | Allan M. Torres, Ian Menz, Paul F. Alewood, Paramjit Bansal, Jelle Lahnstein, Clifford H. Gallagher and Philip W. Kuchel |
Abstract: | The C-type natriuretic peptide from the platypus venom (OvCNP) exists in two forms, OvCNPa and OvCNPb, whose amino acid sequences are identical. Through the use of nuclear magnetic resonance, mass spectrometry, and peptidase digestion studies, we discovered that OvCNPb incorporates a D-amino acid at position 2 in the primary structure. Peptides containing a D-amino acid have been found in lower forms of organism, but this report is the first for a D-amino acid in a biologically active peptide from a mammal. The result implies the existence of a specific isomerase in the platypus that converts an L-amino acid residue in the protein to the D-configuration. |
Keywords: | Venoms Animals Platypus Natriuretic Peptide, C-Type Amino Acids Chromatography, High Pressure Liquid Nuclear Magnetic Resonance, Biomolecular Mass Spectrometry |
Rights: | Copyright © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. |
DOI: | 10.1016/S0014-5793(02)03050-8 |
Published version: | http://dx.doi.org/10.1016/s0014-5793(02)03050-8 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 7 |
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