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https://hdl.handle.net/2440/134088
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Type: | Journal article |
Title: | Neural crest cell-derived VEGF promotes embryonic jaw extension |
Author: | Wiszniak, S. Mackenzie, F.E. Anderson, P. Kabbara, S. Ruhrberg, C. Schwarz, Q. |
Citation: | Proceedings of the National Academy of Sciences of USA, 2015; 112(19):6086-6091 |
Publisher: | National Academy of Sciences |
Issue Date: | 2015 |
ISSN: | 0027-8424 1091-6490 |
Statement of Responsibility: | Sophie Wiszniak, Francesca E. Mackenzie, Peter Anderson, Samuela Kabbara, Christiana Ruhrberg, and Quenten Schwarz |
Abstract: | Jaw morphogenesis depends on the growth of Meckel's cartilage during embryogenesis. However, the cell types and signals that promote chondrocyte proliferation for Meckel's cartilage growth are poorly defined. Here we show that neural crest cells (NCCs) and their derivatives provide an essential source of the vascular endothelial growth factor (VEGF) to enhance jaw vascularization and stabilize the major mandibular artery. We further show in two independent mouse models that blood vessels promote Meckel's cartilage extension. Coculture experiments of arterial tissue with NCCs or chondrocytes demonstrated that NCC-derived VEGF promotes blood vessel growth and that blood vessels secrete factors to instruct chondrocyte proliferation. Computed tomography and X-ray scans of patients with hemifacial microsomia also showed that jaw hypoplasia correlates with mandibular artery dysgenesis. We conclude that cranial NCCs and their derivatives provide an essential source of VEGF to support blood vessel growth in the developing jaw, which in turn is essential for normal chondrocyte proliferation, and therefore jaw extension. |
Keywords: | Neural crest; VEGF; mandible; chondrocyte; blood vessel |
Rights: | Freely available online through the PNAS open access option. |
DOI: | 10.1073/pnas.1419368112 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1073/pnas.1419368112 |
Appears in Collections: | Medicine publications |
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