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https://hdl.handle.net/2440/134529
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dc.contributor.author | McGrady, M. | - |
dc.contributor.author | Reid, C.M. | - |
dc.contributor.author | Shiel, L. | - |
dc.contributor.author | Wolfe, R. | - |
dc.contributor.author | Boffa, U. | - |
dc.contributor.author | Liew, D. | - |
dc.contributor.author | Campbell, D.J. | - |
dc.contributor.author | Prior, D. | - |
dc.contributor.author | Krum, H. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | European Journal of Heart Failure, 2013; 15(5):573-580 | - |
dc.identifier.issn | 1388-9842 | - |
dc.identifier.issn | 1879-0844 | - |
dc.identifier.uri | https://hdl.handle.net/2440/134529 | - |
dc.description.abstract | Aims: Impaired diastolic function is associated with increased morbidity and mortality, but antecedents and predictors of progression to heart failure (HF) are not well understood. We examined associations between NT-proBNP, HF risk factors, and diastolic function in a population at high risk for incident HF. Methods and results: A total of 3550 subjects at high risk for incident HF (≥60 years plus ≥1 HF risk factor), but without pre-existing HF or LV dysfunction were recruited. Participants at highest risk (n ¼ 664) (NT-proBNP in the highest quintile .254 pg/mL) underwent echocardiography. Moderate or severe diastolic dysfunction was observed in 25% [95% confidence interval (CI) 21–29%] of participants. Age (P ¼ 0.001), male gender (P ¼ 0.03), diabetes (P ¼ 0.03), and NT-proBNP (P ¼ 0.002) were associated with severity of diastolic dysfunction after adjustment for HF risk factors and LVEF. In regression analysis, log-transformed NT-proBNP was also associated with LV mass index (P ¼ 0.05), left atrial size (P , 0.0001), and Doppler ratio of the mitral valve E/e’ (P ¼ 0.001). Multiple HF risk factors were present in the majority of participants (.70%), but no association was observed between diastolic dysfunction and the number of risk factors reported (P ¼ 0.3). Conclusion: Diastolic dysfunction was observed in one in four of these high risk subjects (≥ 60 years, HF risk factor, NT-proBNP .254 pg/mL). NT-proBNP, age and diabetes were strongly associated with severity of diastolic dysfunction, whereas other HF risk factors and LVEF were not. More targeted surveillance using a combination of risk factors and biomarkers may improve identification of those at great risk of incident HF. | - |
dc.description.statementofresponsibility | Michele McGrady, Christopher M. Reid, Louise Shiel, Rory Wolfe, Umberto Boffa, Danny Liew, Duncan J. Campbell, David Prior, and Henry Krum | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © The Author 2013. For permissions please email: journals.permissions@oup.com. | - |
dc.source.uri | http://dx.doi.org/10.1093/eurjhf/hft001 | - |
dc.subject | Diastolic dysfunction; Echocardiography; Cardiac biomarker | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Ventricular Dysfunction, Left | - |
dc.subject.mesh | Natriuretic Peptide, Brain | - |
dc.subject.mesh | Peptide Fragments | - |
dc.subject.mesh | Echocardiography | - |
dc.subject.mesh | Echocardiography, Doppler | - |
dc.subject.mesh | Mass Screening | - |
dc.subject.mesh | Severity of Illness Index | - |
dc.subject.mesh | Risk Factors | - |
dc.subject.mesh | Regression Analysis | - |
dc.subject.mesh | Diastole | - |
dc.subject.mesh | Ventricular Remodeling | - |
dc.subject.mesh | Aged | - |
dc.subject.mesh | Aged, 80 and over | - |
dc.subject.mesh | Middle Aged | - |
dc.subject.mesh | Female | - |
dc.subject.mesh | Male | - |
dc.subject.mesh | Heart Failure | - |
dc.subject.mesh | Biomarkers | - |
dc.subject.mesh | Surveys and Questionnaires | - |
dc.title | N-terminal B-type natriuretic peptide and the association with left ventricular diastolic function in a population at high risk of incident heart failure: Results of the SCReening Evaluation of the Evolution of New-Heart Failure Study (SCREEN-HF) | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/eurjhf/hft001 | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Boffa, U. [0000-0001-6261-8891] | - |
dc.identifier.orcid | Liew, D. [0000-0002-0131-623X] | - |
Appears in Collections: | Medicine publications |
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