Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/134738
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Type: | Journal article |
Title: | COVID-19: Can we treat the mother without harming her baby? |
Author: | Wiese, M.D. Berry, M.J. Hissaria, P. Darby, J.R.T. Morrison, J.L. |
Citation: | Journal of Developmental Origins of Health and Disease, 2022; 13(1):9-19 |
Publisher: | Cambridge University Press (CUP) |
Issue Date: | 2022 |
ISSN: | 2040-1744 2040-1752 |
Statement of Responsibility: | Michael D. Wiese, Mary J. Berry, Pravin Hissaria, Jack R.T. Darby, and Janna L. Morrison |
Abstract: | Medical care is predicated on ‘do no harm’, yet the urgency to find drugs and vaccines to treat or prevent COVID-19 has led to an extraordinary effort to develop and test new therapies. Whilst this is an essential cornerstone of a united global response to the COVID-19 pandemic, the absolute requirements for meticulous efficacy and safety data remain. This is especially pertinent to the needs of pregnant women; a group traditionally poorly represented in drug trials, yet a group at heightened risk of unintended adverse materno-fetal consequences due to the unique physiology of pregnancy and the life course implications of fetal or neonatal drug exposure. However, due to the complexities of drug trial participation when pregnant (be they vaccines or therapeutics for acute disease), many clinical drug trials will exclude them. Clinicians must determine the best course of drug treatment with a dearth of evidence from either clinical or preclinical studies, where at least in the short term they may be more focused on the outcome of the mother than of her offspring. |
Keywords: | Pregnancy SARS-CoV-2 COVID-19 treatment medication |
Description: | First published online: 25 January 2021 |
Rights: | © The Author(s), 2021. Published by Cambridge University Press in association with the International Society for Developmental Origins of Health and Disease. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1017/S2040174420001403 |
Grant ID: | http://purl.org/au-research/grants/arc/FT170100431 |
Published version: | http://dx.doi.org/10.1017/s2040174420001403 |
Appears in Collections: | Medicine publications |
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hdl_134738.pdf | Published version | 500.36 kB | Adobe PDF | View/Open |
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