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https://hdl.handle.net/2440/135309
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dc.contributor.author | Dai, Z. | - |
dc.contributor.author | Wang, Q. | - |
dc.contributor.author | Tang, J. | - |
dc.contributor.author | Wu, M. | - |
dc.contributor.author | Li, H. | - |
dc.contributor.author | Yang, Y. | - |
dc.contributor.author | Zhen, X. | - |
dc.contributor.author | Yu, C. | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Biomaterials, 2022; 280:121261-1-121261-13 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://hdl.handle.net/2440/135309 | - |
dc.description.abstract | Immunogenic cell death (ICD) is a promising strategy in cancer immunotherapy to induce high immunogenicity and activate the immune system. However, its efficacy is counteracted by the concurrent exposure of phos- phatidylserine (PS), an immunosuppressive signal on the surface of cancer cells. Here we report the synthesis of a bimetallic metal-organic framework (MOF) nanoparticle containing Gd3+ and Zn2+ (Gd-MOF-5) that can be used as an immunomodulator to downregulate the immunosuppressive PS signal and an ICD inducer to upregulate immunostimulatory signals. Gd3+ inhibits PS externalization via inhibiting the activity of scramblase, an enzyme to transfer PS to the outer leaflet of plasma membrane. Moreover, intracellular Zn2+ overload activates endo- plasmic reticulum stress for ICD induction. In combination with an immune checkpoint inhibitor (PD-L1 anti- body, denoted as aPDL1), Gd-MOF-5 activated potent immune response and effectively inhibited primary and distal tumor growth in a bilateral 4T1 tumor model. This work presents a new strategy using designed MOF materials to modulate the cell signalling and immunosuppressive microenvironment to improve the outcome of cancer immunotherapy. | - |
dc.description.statementofresponsibility | Zan Dai, Qiaoyun Wang, Jie Tang, Min Wu, Haoze Li, Yannan Yang, Xu Zhen, Chengzhong Yu | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.rights | © 2021 Elsevier Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.biomaterials.2021.121261 | - |
dc.subject | Immunogenic Cell Death | - |
dc.subject | Metal-Organic Frameworks | - |
dc.subject | Immunotherapy | - |
dc.subject | Phosphatidylserine | - |
dc.subject | Scramblase | - |
dc.subject.mesh | Cell Line, Tumor | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Neoplasms | - |
dc.subject.mesh | Immunotherapy | - |
dc.subject.mesh | Nanoparticles | - |
dc.subject.mesh | Tumor Microenvironment | - |
dc.subject.mesh | Metal-Organic Frameworks | - |
dc.subject.mesh | Immunogenic Cell Death | - |
dc.title | Immune-regulating bimetallic metal-organic framework nanoparticles designed for cancer immunotherapy | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2021.121261 | - |
dc.relation.grant | ARC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Yang, Y. [0000-0001-6696-3879] | - |
Appears in Collections: | Chemical Engineering publications |
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