Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/135858
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Type: | Journal article |
Title: | Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia |
Author: | Mateos, M.K. Marshall, G.M. Barbaro, P.M. Quinn, M.C. George, C. Mayoh, C. Sutton, R. Revesz, T. Giles, J.E. Barbaric, D. Alvaro, F. Mechinaud, F. Catchpoole, D. Lawson, J.A. Chenevix-Trench, G. MacGregor, S. Kotecha, R.S. Dalla-Pozza, L. Trahair, T.N. |
Citation: | Haematologica: the hematology journal, 2022; 107(3):635-643 |
Publisher: | Ferrata Storti Foundation (Haematologica) |
Issue Date: | 2022 |
ISSN: | 0390-6078 1592-8721 |
Statement of Responsibility: | Marion K. Mateos, Glenn M Marshall, Pasquale M. Barbaro, Michael C.J. Quinn, Carly George, Chelsea Mayoh, Rosemary Sutton, Tamas Revesz, Jodie E Giles, Draga Barbaric, Frank Alvaro, Françoise Mechinaud, Daniel Catchpoole, John A. Lawson, Georgia Chenevix-Trench, Stuart MacGregor, Rishi S.Kotecha, Luciano Dalla-Pozza, and Toby N. Trahai |
Abstract: | Symptomatic methotrexate-related central neurotoxicity (MTX neurotoxicity) is a severe toxicity experienced during acute lymphoblastic leukemia (ALL) therapy with potential long-term neurologic complications. Risk factors and long-term outcomes require further study. We conducted a systematic, retrospective review of 1,251 consecutive Australian children enrolled on Berlin-Frankfurt-Münster or Children's Oncology Group-based protocols between 1998-2013. Clinical risk predictors for MTX neurotoxicity were analyzed using regression. A genome-wide association study (GWAS) was performed on 48 cases and 537 controls. The incidence of MTX neurotoxicity was 7.6% (n=95 of 1,251), at a median of 4 months from ALL diagnosis and 8 days after intravenous or intrathecal MTX. Grade 3 elevation of serum aspartate aminotransferase (P=0.005, odds ratio 2.31 [range, 1.28–4.16]) in induction/consolidation was associated with MTX neurotoxicity, after accounting for the only established risk factor, age ≥10 years. Cumulative incidence of CNS relapse was increased in children where intrathecal MTX was omitted following symptomatic MTX neurotoxicity (n=48) compared to where intrathecal MTX was continued throughout therapy (n=1,174) (P=0.047). Five-year central nervous system relapse-free survival was 89.2±4.6% when intrathecal MTX was ceased compared to 95.4±0.6% when intrathecal MTX was continued. Recurrence of MTX neurotoxicity was low (12.9%) for patients whose intrathecal MTX was continued after their first episode. The GWAS identified single-nucletide polymorphism associated with MTX neurotoxicity near genes regulating neuronal growth, neuronal differentiation and cytoskeletal organization (P<1x10-6). In conclusion, increased serum aspartate aminotransferase and age ≥10 years at diagnosis were independent risk factors for MTX neurotoxicity. Our data do not support cessation of intrathecal MTX after a first MTX neurotoxicity event. |
Keywords: | Humans Methotrexate Antineoplastic Combined Chemotherapy Protocols Injections, Spinal Risk Factors Child Australia Precursor Cell Lymphoblastic Leukemia-Lymphoma Genome-Wide Association Study |
Rights: | ©2022 Ferrata Storti Foundation Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher. |
DOI: | 10.3324/haematol.2020.268565 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1056667 http://purl.org/au-research/grants/nhmrc/1142627 |
Published version: | http://dx.doi.org/10.3324/haematol.2020.268565 |
Appears in Collections: | Medicine publications |
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