Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/136850
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Type: | Journal article |
Title: | Personalized brain stimulation of memory networks |
Author: | Cash, R.F.H. Hendrikse, J. Fernando, K.B. Thompson, S. Suo, C. Fornito, A. Yücel, M. Rogasch, N.C. Zalesky, A. Coxon, J.P. |
Citation: | Brain Stimulation, 2022; 15(5):1300-1304 |
Publisher: | Elsevier |
Issue Date: | 2022 |
ISSN: | 1935-861X 1876-4754 |
Statement of Responsibility: | Robin F.H. Cash, Joshua Hendrikse, Kavisha B Fernando, Sarah Thompson, Chao Suo, Alex Fornito, Murat Yücel, Nigel C. Rogasch, Andrew Zalesky, James P. Coxon |
Abstract: | Background: The finding that transcranial magnetic stimulation (TMS) can enhance memory performance via stimulation of parietal sites within the Cortical-Hippocampal Network counts as one of the most exciting findings in this field in the past decade. However, the first independent effort aiming to fully replicate this finding found no discernible influence of TMS on memory performance. Objective: We examined whether this might relate to interindividual spatial variation in brain connectivity architecture, and the capacity of personalisation methodologies to overcome the noise inherent across independent scanners and cohorts. Methods: We implemented recently detailed personalisation methodology to retrospectively compute individual-specific parietal targets and then examined relation to TMS outcomes. Results: Closer proximity between actual and novel fMRI-personalized targets associated with greater improvement in memory performance. Conclusion: These findings demonstrate the potential importance of aligning brain stimulation targets according to individual-specific differences in brain connectivity, and extend upon recent findings in prefrontal cortex. |
Keywords: | Connectivity Memory MRI Personalisation Precision TMS |
Description: | Available online 13 September 2022 |
Rights: | © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
DOI: | 10.1016/j.brs.2022.09.004 |
Grant ID: | http://purl.org/au-research/grants/arc/DE200101708 http://purl.org/au-research/grants/nhmrc/1136649 http://purl.org/au-research/grants/arc/DP200100234 |
Published version: | http://dx.doi.org/10.1016/j.brs.2022.09.004 |
Appears in Collections: | Medicine publications |
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hdl_136850.pdf | Published version | 937.85 kB | Adobe PDF | View/Open |
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