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https://hdl.handle.net/2440/137119
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Type: | Journal article |
Title: | Molecular evolution and functional modification of plant miRNAs with CRISPR. |
Author: | Deng, F. Zeng, F. Shen, Q. Abbas, A. Cheng, J. Jiang, W. Chen, G. Shah, A.N. Holford, P. Tanveer, M. Zhang, D. Chen, Z.-H. |
Citation: | Trends in Plant Science, 2022; 27(9):890-907 |
Publisher: | Elsevier BV |
Issue Date: | 2022 |
ISSN: | 1360-1385 1878-4372 |
Statement of Responsibility: | Fenglin Deng, Fanrong Zeng, Qiufang Shen, Asad Abbas, Jianhui Cheng, Wei Jiang, Guang Chen, Adnan Noor Shah, Paul Holford, Mohsin Tanveer, Dabing Zhang, and Zhong-Hua Chen |
Abstract: | Gene editing using clustered regularly interspaced short palindromic repeat/CRISPR-associated proteins (CRISPR/Cas) has revolutionized biotechnology and provides genetic tools for medicine and life sciences. However, the application of this technology to miRNAs, with the function as negative gene regulators, has not been extensively reviewed in plants. Here, we summarize the evolution, biogenesis, and structure of miRNAs, as well as their interactions with mRNAs and computational models for predicting target genes. In addition, we review current advances in CRISPR/Cas for functional analysis and for modulating miRNA genes in plants. Extending our knowledge of miRNAs and their manipulation with CRISPR will provide fundamental understanding of the functions of plant miRNAs and facilitate more sustainable and publicly acceptable genetic engineering of crops. |
Keywords: | CRISPR/Cas gene editing miRNA–mRNA interactions molecular evolution phylogenetic analysis |
Rights: | © 2022 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.tplants.2022.01.009 |
Grant ID: | http://purl.org/au-research/grants/arc/FT210100366 http://purl.org/au-research/grants/arc/DE1401011143 |
Published version: | http://dx.doi.org/10.1016/j.tplants.2022.01.009 |
Appears in Collections: | Agriculture, Food and Wine publications |
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