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https://hdl.handle.net/2440/137655
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Type: | Journal article |
Title: | Nanoparticles Targeted to Fibroblast Activation Protein Outperform PSMA for MRI Delineation of Primary Prostate Tumors |
Author: | Dmochowska, N. Milanova, V. Mukkamala, R. Chow, K.K. Pham, N.T.H. Srinivasarao, M. Ebert, L.M. Stait-Gardner, T. Le, H. Shetty, A. Nelson, M. Low, P.S. Thierry, B. |
Citation: | Small, 2023; 19(21):2204956-1-2204956-14 |
Publisher: | Wiley |
Issue Date: | 2023 |
ISSN: | 1613-6810 1613-6829 |
Statement of Responsibility: | Nicole Dmochowska, Valentina Milanova, Ramesh Mukkamala, Kwok Keung Chow, Nguyen T. H. Pham, Madduri Srinivasarao, Lisa M. Ebert, Timothy Stait-Gardner, Hien Le, Anil Shetty, Melanie Nelson, Philip S. Low, and Benjamin Thierry |
Abstract: | Accurate delineation of gross tumor volumes remains a barrier to radiotherapy dose escalation and boost dosing in the treatment of solid tumors, such as prostate cancer. Magnetic resonance imaging (MRI) of tumor targets has the power to enable focal dose boosting, particularly when combined with technological advances such as MRI-linear accelerator. Fibroblast activation protein (FAP) is overexpressed in stromal components of >90% of epithelial carcinomas. Herein, the authors compare targeted MRI of prostate specific membrane antigen (PSMA) with FAP in the delineation of orthotopic prostate tumors. Control, FAP, and PSMA-targeting iron oxide nanoparticles were prepared with modification of a lymphotropic MRI agent (FerroTrace, Ferronova). Mice with orthotopic LNCaP tumors underwent MRI 24 h after intravenous injection of nanoparticles. FAP and PSMA nanoparticles produced contrast enhancement on MRI when compared to control nanoparticles. FAP-targeted MRI increased the proportion of tumor contrast-enhancing black pixels by 13%, compared to PSMA. Analysis of changes in R2 values between healthy prostates and LNCaP tumors indicated an increase in contrast-enhancing pixels in the tumor border of 15% when targeting FAP, compared to PSMA. This study demonstrates the preclinical feasibility of PSMA and FAP-targeted MRI which can enable targeted image-guided focal therapy of localized prostate cancer. |
Keywords: | fibroblast activation proteins iron oxide nanoparticles magnetic resonance imaging prostate cancer prostate-specific membrane antigen |
Description: | Published online: February 25, 2023 |
Rights: | © 2023 The Authors. Small published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1002/smll.202204956 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1158755 |
Published version: | http://dx.doi.org/10.1002/smll.202204956 |
Appears in Collections: | Medicine publications |
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hdl_137655.pdf | Published version | 4.82 MB | Adobe PDF | View/Open |
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