Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/138523
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Type: | Journal article |
Title: | Protein Ingestion in Reducing the Risk of Late-Onset Post-Exercise Hypoglycemia: A Pilot Study in Adolescents and Youth with Type 1 Diabetes |
Author: | Paramalingam, N. Keating, B.L. Chetty, T. Fournier, P.A. Soon, W.H.K. O’Dea, J.M. Roberts, A.G. Horowitz, M. Jones, T.W. Davis, E.A. |
Citation: | Nutrients, 2023; 15(3):1-8 |
Publisher: | MDPI AG |
Issue Date: | 2023 |
ISSN: | 2072-6643 2072-6643 |
Statement of Responsibility: | Nirubasini Paramalingam, Barbara L. Keating, Tarini Chetty, Paul A. Fournier, Wayne H. K. Soon, Joanne M. O, Dea, Alison G. Roberts, Michael Horowitz, Timothy W. Jones, and Elizabeth A. Davis |
Abstract: | Dietary protein causes dose-dependent hyperglycemia in individuals with type 1 diabetes (T1D). This study investigated the effect of consuming 50 g of protein on overnight blood glucose levels (BGLs) following late-afternoon moderate-intensity exercise. Six participants (3M:3F) with T1D, HbA1c 7.5 ± 0.8% (58.0 ± 8.7 mmol/mol) and aged 20.2 ± 3.1 years exercised for 45 min at 1600 h and consumed a protein drink or water alone at 2000 h, on two separate days. A basal insulin euglycemic clamp was employed to measure the mean glucose infusion rates (m-GIR) required to maintain euglycemia on both nights. The m-GIR on the protein and water nights during the hypoglycemia risk period and overnight were 0.27 ± 043 vs. 1.60 ± 0.66 mg/kg/min (p = 0.028, r = 0.63) and 0.51 ± 0.16 vs. 1.34 ± 0.71 mg/kg/min (p = 0.028, r = 0.63), respectively. Despite ceasing intravenous glucose infusion on the protein night, the BGLs peaked at 9.6 ± 1.6 mmol/L, with a hypoglycemia risk period mean of 7.8 ± 1.5 mmol/L compared to 5.9 ± 0.4 mmol/L (p = 0.028) on the water night. The mean plasma glucagon levels were 51.5 ± 14.1 and 27.2 ± 10.1 ng/L (p = 0.028) on the protein and water night, respectively. This suggests that an intake of protein is effective at reducing the post-exercise hypoglycemia risk, potentially via a glucagon-mediated stimulation of glucose production. However, 50 g of protein may be excessive for maintaining euglycemia. |
Keywords: | type 1 diabetes; protein; LOPEH; glucagon; moderate intensity exercise; hypoglycemia |
Rights: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
DOI: | 10.3390/nu15030543 |
Grant ID: | ARC |
Published version: | http://dx.doi.org/10.3390/nu15030543 |
Appears in Collections: | Medicine publications |
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hdl_138523.pdf | Published version | 576.46 kB | Adobe PDF | View/Open |
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