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https://hdl.handle.net/2440/138568
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Type: | Journal article |
Title: | The effects of age and biological sex on the association between I-wave recruitment and the response to cTBS: an exploratory study |
Author: | Van Dam, J.M. Graetz, L. Pitcher, J.B. Goldsworthy, M.R. |
Citation: | Brain Research, 2023; 180:148359-1-148359-8 |
Publisher: | Elsevier |
Issue Date: | 2023 |
ISSN: | 0006-8993 1872-6240 |
Statement of Responsibility: | Jago M. Van Dam, Lynton Graetz, Julia B. Pitcher, Mitchell R. Goldsworthy |
Abstract: | The neuroplastic response to continuous theta burst stimulation (cTBS) is inherently variable. The measurement of I-wave latencies has been shown to strongly predict the magnitude and direction of the response to cTBS, whereby longer latencies are associated with stronger long-term depression-like responses. However, potential differences in this association relating to age and sex have not been explored. We performed cTBS and measured I-wave recruitment (via MEP latencies) in 66 participants (31 female) ranging in age from 11 to 78 years. The influence of age and sex on the association between I-wave recruitment and the response to cTBS was tested using linear regression models. In contrast to previous studies, there was not a significant association between Iwave latencies and cTBS response at the group level (p = 0.142, R2 = 0.033). However, there were interactions between I-waves and both age and sex when predicting cTBS response. Subgroup analysis revealed that preferential late I-wave recruitment predicted cTBS response in adolescent females, but not in adolescent or adult males or adult females. These data suggest that the generalisability of I-wave measurement in predicting the response to cTBS may be lower than initially believed. Prediction models should include age and sex, rather than I-wave latencies alone, as our findings suggest that, while each factor alone is not a strong predictor, these factors interact to influence the response to cTBS. |
Keywords: | transcranial magnetic stimulation continuous theta burst stimulation neuroplasticity I-waves sex neurodevelopment |
Rights: | © 2023 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.brainres.2023.148359 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1102272 http://purl.org/au-research/grants/arc/DE200100575 |
Published version: | http://dx.doi.org/10.1016/j.brainres.2023.148359 |
Appears in Collections: | Molecular and Biomedical Science publications |
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