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https://hdl.handle.net/2440/138910
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Type: | Journal article |
Title: | The health outcomes of human offspring conceived by assisted reproductive technologies (ART) |
Author: | Chen, M. Heilbronn, L.K. |
Citation: | Journal of Developmental Origins of Health and Disease, 2017; 8(4):388-402 |
Publisher: | Cambridge University Press (CUP) |
Issue Date: | 2017 |
ISSN: | 2040-1744 2040-1752 |
Statement of Responsibility: | M. Chen and L. K. Heilbronn |
Abstract: | Concerns have been raised about the health and development of children conceived by assisted reproductive technologies (ART) since 1978. Controversially, ART has been linked with adverse obstetric and perinatal outcomes, an increased risk of birth defects, cancers, and growth and development disorders. Emerging evidence suggests that ART treatment may also predispose individuals to an increased risk of chronic ageing related diseases such as obesity, type 2 diabetes and cardiovascular disease. This review will summarize the available evidence on the short-term and long-term health outcomes of ART singletons, as multiple pregnancies after multiple embryos transfer, are associated with low birth weight and preterm delivery, which can separately increase risk of adverse postnatal outcomes, and impact long-term health. We will also examine the potential factors that may contribute to these health risks, and discuss underlying mechanisms, including epigenetic changes that may occur during the preimplantation period and reprogram development in utero, and adult health, later in life. Lastly, this review will consider the future directions with the view to optimize the long-term health of ART children. |
Keywords: | assisted reproductive technologies (ART); In vitro fertilization (IVF); intracytoplasmic sperm injection (ICSI); singletons; health outcomes |
Description: | Themed Issue: Assisted Reproductive Treatments (ART) and DOHAD |
Rights: | © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017 |
DOI: | 10.1017/S2040174417000228 |
Grant ID: | http://purl.org/au-research/grants/arc/FT120100027 |
Published version: | http://dx.doi.org/10.1017/s2040174417000228 |
Appears in Collections: | Medicine publications |
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