Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/139201
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Type: | Journal article |
Title: | Case report: Rare case of donor cell-derived T-cell acute lymphoblastic leukaemia in a female patient after receiving an allo-transplant from her male sibling |
Author: | Eadie, L.N. Rehn, J.A. Schutz, C.E. Heatley, S.L. Kutyna, M.M. Hiwase, D.K. White, D.L. Yeung, D.T. |
Citation: | British Journal of Haematology, 2023; 203(2):282-287 |
Publisher: | Wiley |
Issue Date: | 2023 |
ISSN: | 0007-1048 1365-2141 |
Statement of Responsibility: | Laura N. Eadie, Jacqueline A. Rehn, Caitlin E. Schutz, Susan L. Heatley, Monika M. Kutyna, Devendra K. Hiwase, Deborah L. White, David T. Yeung |
Abstract: | Donor-derived haematological neoplasms, in which recipients present with haematological malignancies that have evolved from transplant donor stem cells, have previously been described for myelodysplastic syndrome, myeloproliferative neoplasms, acute myeloid leukaemia and less often, leukaemias of lymphoid origin. Here we describe a rare and complex case of donor-derived T-cell acute lymphoblastic leukaemia with a relatively short disease latency of less than 4 years. Through genomic and in vitro analyses, we identified novel mutations in NOTCH1 as well as a novel activating mutation in STAT5B; the latter targetable with the clinically available drugs, venetoclax and ruxolitinib. |
Keywords: | acute lymphoblastic leukaemia; case report; chromosomal abnormalities; CNOT3; DNMT3A; donor-derived haematological neoplasms; KMT2D; mRNA-sequencing; NOTCH1; precision medicine; STAT5B |
Description: | First published: 31 July 2023 |
Rights: | © 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
DOI: | 10.1111/bjh.19008 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1146253 http://purl.org/au-research/grants/nhmrc/1160833 |
Published version: | http://dx.doi.org/10.1111/bjh.19008 |
Appears in Collections: | Medicine publications |
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hdl_139201.pdf | Published version | 2 MB | Adobe PDF | View/Open |
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