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https://hdl.handle.net/2440/140209
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Type: | Journal article |
Title: | Can an intervention with testosterone and nutritional supplement improve the frailty level of under-nourished older people? |
Author: | Theou, O. Chapman, I. Wijeyaratne, L. Piantadosi, C. Lange, K.M. Naganathan, V. Hunter, P. Cameron, I.D. Rockwood, K. Visvanathan, R. |
Citation: | The Journal of Frailty and Aging, 2016; 5(4):247-252 |
Publisher: | SERDI Publisher |
Issue Date: | 2016 |
ISSN: | 2260-1341 2273-4309 |
Statement of Responsibility: | O. Theou, I. Chapman, L. Wijeyaratne, C. Piantadosi, K. Lange, V. Naganathan, P. Hunter, I.D. Cameron, K. Rockwood, R. Visvanathan |
Abstract: | Objective: To examine whether a testosterone and a high calorie nutritional supplement intervention can reduce frailty scores in undernourished older people using multiple frailty tools. Design: Randomized controlled trial. Setting/Participants: 53 community-dwelling, undernourished men and women aged >65 years from South Australia, Victoria and New South Wales. Intervention: Intervention group received oral testosterone undecanoate and a high calorie supplement (2108-2416 kJ/day) whereas the control group received placebo testosterone and low calorie supplement (142-191 kJ/day). Measurements: Frailty was operationalized using three frailty indices (FI-lab, FI-self-report, FI-combined) and the frailty phenotype. Results: There were no significant differences in changes in frailty scores at either 6 or 12 months follow up between the two treatment groups for all scales. Participants at the intervention group were 4.8 times more likely to improve their FI-combined score at both time points compared to the placebo group. Conclusion: A testosterone and a high calorie nutritional supplement intervention did not improve the frailty levels of under-nourished older people. Even so, when frailty was measured using a frailty index combining self-reported and lab data we found that participants who received the intervention were more likely to show persistent improvement in their frailty scores. |
Keywords: | aging; Frail elderly; frailty index; Geriatrics & Gerontology; Life Sciences & Biomedicine; nutrition; older adults; Science & Technology; testosterone |
Rights: | © 2016 - The Journal of Frailty & Aging |
DOI: | 10.14283/jfa.2016.108 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/627178 |
Published version: | https://www.jfrailtyaging.com/all-issues.html?article=450 |
Appears in Collections: | Medicine publications |
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