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https://hdl.handle.net/2440/14328
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Type: | Journal article |
Title: | Lack of effect of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen in human. |
Author: | Knights, K. McLean, C. Tonkin, A. Miners, J. |
Citation: | British Journal of Clinical Pharmacology, 1995; 40(2):153-156 |
Publisher: | Blackwell Scientific |
Issue Date: | 1995 |
ISSN: | 0306-5251 1365-2125 |
Statement of Responsibility: | Knights, Km ; Mclean, Cf ; Tonkin, Al ; Miners, Jo |
Abstract: | The effects of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen were studied in groups of healthy adult males, females and oral contraceptive steroid (OCS) using females. The values of AUC, CLpo, t1/2 and Vss, app did not differ significantly between the groups. Similarly, the percentage unbound of (R)-ibuprofen in pooled plasma from the three groups was not statistically different. Since chiral inversion is the major determinant of (R)-ibuprofen clearance in humans, it may be inferred from these data that gender and OCS have little or no effect on conversion of (R)-ibuprofen to the pharmacologically active S-enantiomer. Moreover, it is unlikely that hormonal factors influence the activity of the human hepatic long-chain fatty-acid:CoA ligase, the enzyme mediating the rate limiting step of (R)-ibuprofen inversion. |
Keywords: | Humans Ibuprofen Contraceptives, Oral, Hormonal Anti-Inflammatory Agents, Non-Steroidal Administration, Oral Analysis of Variance Sex Factors Stereoisomerism Adolescent Adult Female Male |
DOI: | 10.1111/j.1365-2125.1995.tb05769.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2125.1995.tb05769.x |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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