Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/17455
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Brennan, I. | - |
dc.contributor.author | Feltrin, K. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Smout, A. | - |
dc.contributor.author | Meyer, J. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2005; 288(6):R1477-R1485 | - |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.issn | 1522-1490 | - |
dc.identifier.uri | http://hdl.handle.net/2440/17455 | - |
dc.description | Published abstract used with permission of the copyright owner. | - |
dc.description.abstract | There is evidence that CCK and glucagon-like peptide-1 (GLP-1) mediate the effects of nutrients on appetite and gastrointestinal function and that their interaction may be synergistic. We hypothesized that intravenous CCK-8 and GLP-1 would have synergistic effects on appetite, energy intake, and antropyloroduodenal (APD) motility. Nine healthy males (age 22 ± 1 yr) were studied on four separate days in a double-blind, randomized fashion. Appetite and APD pressures were measured during 150-min intravenous infusions of 1) isotonic saline (control), 2) CCK-8 (1.8 pmol·kg–1·min–1), 3) GLP-1 (0.9 pmol·kg–1·min–1), or 4) both CCK-8 (1.8 pmol·kg–1·min–1) and GLP-1 (0.9 pmol·kg–1·min–1). At 120 min, energy intake at a buffet meal was quantified. CCK-8, but not GLP-1, increased fullness, decreased desire to eat and subsequent energy intake, and increased the number and amplitude of isolated pyloric pressure waves and basal pyloric pressure (P < 0.05). Both CCK-8 and GLP-1 decreased the number of antral and duodenal pressure waves (PWs) (P < 0.05), and CCK-8+GLP-1 decreased the number of duodenal PWs more than either CCK-8 or GLP-1 alone (P < 0.02). This was not the case for appetite or isolated pyloric PWs. In conclusion, at the doses evaluated, exogenously administered CCK-8 and GLP-1 had discrepant effects on appetite, energy intake, and APD pressures, and the effects of CCK-8+GLP-1, in combination, did not exceed the sum of the effects of CCK-8 and GLP-1, providing no evidence of synergism. | - |
dc.description.statementofresponsibility | Ixchel M. Brennan, Kate L. Feltrin, Michael Horowitz, Andre J. P. M. Smout, James H. Meyer, Judith Wishart, and Christine Feinle-Bisset | - |
dc.language.iso | en | - |
dc.publisher | Amer Physiological Soc | - |
dc.rights | Copyright © 2005 American Physiological Society | - |
dc.source.uri | http://dx.doi.org/10.1152/ajpregu.00732.2004 | - |
dc.subject | Duodenum | - |
dc.subject | Pyloric Antrum | - |
dc.subject | Humans | - |
dc.subject | Nausea | - |
dc.subject | Cholecystokinin | - |
dc.subject | Glucagon | - |
dc.subject | Peptide Fragments | - |
dc.subject | Protein Precursors | - |
dc.subject | Infusions, Intravenous | - |
dc.subject | Double-Blind Method | - |
dc.subject | Appetite | - |
dc.subject | Satiety Response | - |
dc.subject | Energy Intake | - |
dc.subject | Gastrointestinal Motility | - |
dc.subject | Drug Synergism | - |
dc.subject | Pressure | - |
dc.subject | Reference Values | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Male | - |
dc.subject | Glucagon-Like Peptide 1 | - |
dc.title | Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpregu.00732.2004 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
Appears in Collections: | Aurora harvest 2 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.