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https://hdl.handle.net/2440/23138
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Type: | Journal article |
Title: | Neonatal adrenal function after repeat dose prenatal corticosteroids: A randomized controlled trial |
Author: | Ashwood, P. Crowther, C. Willson, K. Haslam, R. Kennaway, D. Hiller, J. Robinson, J. |
Citation: | American Journal of Obstetrics and Gynecology, 2006; 194(3):861-867 |
Publisher: | Mosby Inc |
Issue Date: | 2006 |
ISSN: | 0002-9378 1097-6868 |
Statement of Responsibility: | Patricia J. Ashwood; Caroline A. Crowther; Kristyn J. Willson; Ross R. Haslam; David J. Kennaway; Janet E. Hiller; and Jeffrey S. Robinson |
Abstract: | <h4>Objective</h4>Do repeat prenatal corticosteroids suppress neonatal cortisol concentrations?<h4>Study design</h4>Randomized controlled trial of women given weekly repeat corticosteroids or saline placebo, while at risk of preterm birth, until 32 weeks' gestation.<h4>Results</h4>Cord serum cortisol concentrations in infants exposed to repeat corticosteroids were similar compared with infants exposed to a single course of corticosteroids (mean difference -26 nmol/L (95% CI -57, 5 nmol/L, P = .10), as were prestress salivary cortisol concentrations on day 3 (median 16.5 vs 15.3 nmol/L, P = .96). The adrenal response to a stressor on day 3 was lower in the repeat corticosteroid group compared with the single course group (median 11.9 vs 21.4 nmol/L, P = .02). Cortisol concentrations were lower in the repeat corticosteroid group on day 7 (median 11.7 vs 18.2 nmol/L, P = .04), but not on days 14 and 21.<h4>Conclusion</h4>The short- or long-term clinical impact, if any, of these changes in adrenal function needs to be determined. |
Keywords: | Repeat corticosteroids Neonatal adrenal suppression Randomized trial |
Description: | Copyright © 2006 Mosby, Inc. All rights reserved. |
DOI: | 10.1016/j.ajog.2005.08.063 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/623277/description#description |
Published version: | http://dx.doi.org/10.1016/j.ajog.2005.08.063 |
Appears in Collections: | Aurora harvest 2 Obstetrics and Gynaecology publications |
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