Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/23357
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Testosterone improves motor function in Parkinson's disease |
Author: | Mitchell, E. Thomas, D. Burnet, R. |
Citation: | Journal of Clinical Neuroscience, 2006; 13(1):133-136 |
Publisher: | Churchill Livingstone |
Issue Date: | 2006 |
ISSN: | 0967-5868 1532-2653 |
Abstract: | In Parkinson's disease (PD) there is increasing evidence that sex steroids such as estradiol and testosterone modulate, either as a positive or negative effect, the clinical expression of a variety of movement disorders involving the nigrostriatum. Testosterone deficiency is common in the older male population and has an increased prevalence in parkinsonian patients. Testosterone therapy has been shown to improve the non-motor symptoms of PD but evidence for a direct effect of testosterone on motor symptoms is lacking. This case report demonstrates a significant improvement in the resting tremor and fine motor control after testosterone administration in a parkinsonian patient with testosterone deficiency (1 nmol/L). Motor symptom change was shown by serial assessment of the patient's handwriting, self-reporting using the Unified Parkinson's Disease Rating Scale and measurement of resting tremor amplitude by an accelerometer. The improvement in motor symptoms correlated with serum testosterone levels. The use of testosterone replacement in those men with decreased levels may improve the motor symptoms as well as increase general wellbeing. |
Keywords: | Humans Parkinson Disease Tremor Testosterone Androgens Psychomotor Performance Time Factors Handwriting Aged, 80 and over Male |
DOI: | 10.1016/j.jocn.2005.02.014 |
Published version: | http://dx.doi.org/10.1016/j.jocn.2005.02.014 |
Appears in Collections: | Aurora harvest 2 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.