Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/23435
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | A system for improving vitamin D nutrition in residential care |
Author: | Wigg, A. Prest, C. Slobodian, P. Need, A. Cleland, L. |
Citation: | Medical Journal of Australia, 2006; 185(4):195-198 |
Publisher: | Australasian Med Publ Co Ltd |
Issue Date: | 2006 |
ISSN: | 0025-729X 1326-5377 |
Statement of Responsibility: | Alison E R Wigg, Caroline Prest, Peter Slobodian, Allan G Need and Leslie G Cleland |
Abstract: | Objective: To assess the feasibility of administering an inexpensive preparation of vitamin D3 100 000 IU orally 3 monthly to aged-care residents. Design: Prospective, controlled open-label implementation trial. Setting: Residential aged care, November 2003 to May 2004 (primary study). Participants: 137 ambulant residents: 107 treated (mean age, 85 years; 79 were women), 30 untreated controls (mean age, 87 years; 22 were women). Interventions: Lactose microencapsulated vitamin D3 100 000 IU orally at baseline, then 3 monthly (three or more doses); untreated subjects were observed contemporaneously. Main outcome measures: Serum levels of 25-hydroxyvitamin D [25(OH)D] at 6 months compared with baseline; acceptability of the program to residents and staff. Results: At baseline, 95% of residents assessed (n = 137) had serum 25(OH)D levels below the desirable range of 60–160 nmol/L. At 6 months, all treated residents (n = 98) achieved desired levels, with the mean (± SD) 25(OH)D level increasing from 36.4 ± 12.6 nmol/L (range, 12–75 nmol/L) at baseline to 124.0 ± 27.9 nmol/L (range, 68–244 nmol/L). In no resident did 25(OH)D approach toxic levels. The mean serum 25(OH)D level remained low in the control group (n = 27): 42.8 ± 18.3 nmol/L (range, 18–98 nmol/L). The difference between the mean 25(OH)D levels of treatment and control groups at 6 months was 81.2 nmol/L (95% CI, 69.7–92.0 nmol/L). The cost of the supplement was $4 per resident per annum. Substudies showed mean trough serum 25(OH)D levels in the desired range at 3 months (n = 31), but below the desired range at 6 months (n = 50). Subjects given 3-monthly doses for up to 2 years maintained serum 25(OH)D levels within the desired range, with no trend toward undesirable accumulation (n = 11). Conclusions: Vitamin D3 100 000 IU given orally 3 monthly is a practical, safe, effective and inexpensive way to meet the vitamin D3 requirements of aged-care residents. |
Keywords: | Humans Vitamin D Deficiency Cholecalciferol Vitamin D Administration, Oral Prospective Studies Feasibility Studies Aged Aged, 80 and over Homes for the Aged Female Male Surveys and Questionnaires |
Description: | The document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included. |
DOI: | 10.5694/j.1326-5377.2006.tb00530.x |
Published version: | http://www.mja.com.au/public/issues/185_04_210806/wig10038_fm.html |
Appears in Collections: | Aurora harvest 2 Medicine publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
23435_hdl.pdf | Published version | 267.29 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.