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https://hdl.handle.net/2440/23460
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Type: | Journal article |
Title: | Pharmacological treatments for thyroid eye disease |
Author: | Modjtahedi, S. Modjtahedi, B. Mansury, A. Selva-Nayagam, D. Douglas, R. Goldberg, R. Leibovitch, I. |
Citation: | Drugs, 2006; 66(13):1685-1700 |
Publisher: | Adis International Ltd |
Issue Date: | 2006 |
ISSN: | 0012-6667 0012-6667 |
Statement of Responsibility: | Sara P. Modjtahedi, Bobeck S. Modjtahedi, Ahmad M. Mansury, Dinesh Selva, Raymond S. Douglas, Robert A. Goldberg and Igal Leibovitch |
Abstract: | Thyroid eye disease (TED), which affects the majority of patients with Grave's disease, is associated with significant ophthalmic morbidity. In patients with mild disease, supportive treatment with lubricating medication can be sufficient. However, in patients with severe TED and disfiguring proptosis or sight-threatening neuropathy, more aggressive medical or surgical interventions are necessary. Corticosteroids remain the preferred pharmacological treatment modality in the majority of patients with an active inflammatory component. Other immunosuppressive drugs in combination with corticosteroids may be helpful in patients with corticosteroid-resistant TED. Newer agents such as somatostatin analogues have not shown to be of significant clinical benefit; however, initial studies on the use of antioxidants and cytokine antagonists are encouraging. |
Keywords: | Humans Adrenal Cortex Hormones Immunosuppressive Agents Drug Therapy, Combination Drug Resistance Graves Ophthalmopathy |
DOI: | 10.2165/00003495-200666130-00003 |
Published version: | http://adisonline.com/drugs/Fulltext/2006/66130/Pharmacological_Treatments_for_Thyroid_Eye_Disease.3.aspx |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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