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https://hdl.handle.net/2440/28129
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Type: | Journal article |
Title: | A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead |
Author: | Wilanowski, T. Tuckfield, A. Cerruti, L. O'Connell, S. Saint, R. Parekh, V. Tao, J. Cunningham, J. Jane, S. |
Citation: | Mechanisms of Development, 2002; 114(1-2):37-50 |
Publisher: | Elsevier Science BV |
Issue Date: | 2002 |
ISSN: | 0925-4773 1872-6356 |
Organisation: | Centre for the Molecular Genetics of Development |
Abstract: | The Drosophila transcription factor Grainyhead regulates several key developmental processes. Three mammalian genes, CP2, LBP-1a and LBP-9 have been previously identified as homologues of grainyhead. We now report the cloning of two new mammalian genes (Mammalian grainyhead (MGR) and Brother-of-MGR (BOM)) and one new Drosophila gene (dCP2) that rewrite the phylogeny of this family. We demonstrate that MGR and BOM are more closely related to grh, whereas CP2, LBP-1a and LBP-9 are descendants of the dCP2 gene. MGR shares the greatest sequence homology with grh, is expressed in tissue-restricted patterns more comparable to grh and binds to and transactivates the promoter of the human Engrailed-1 gene, the mammalian homologue of the key grainyhead target gene, engrailed. This sequence and functional conservation indicates that the new mammalian members of this family play important developmental roles. |
Keywords: | Grainyhead Homologue |
DOI: | 10.1016/S0925-4773(02)00046-1 |
Description (link): | http://www.sciencedirect.com/science/journal/09254773 |
Published version: | http://dx.doi.org/10.1016/s0925-4773(02)00046-1 |
Appears in Collections: | Aurora harvest 6 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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