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https://hdl.handle.net/2440/2972
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DC Field | Value | Language |
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dc.contributor.author | Coates, A. | - |
dc.contributor.author | Heilbronn, L. | - |
dc.contributor.author | Noakes, M. | - |
dc.contributor.author | Kind, K. | - |
dc.contributor.author | Clifton, P. | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Diabetes Research and Clinical Practice, 2003; 62(3):197-201 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.issn | 1872-8227 | - |
dc.identifier.uri | http://hdl.handle.net/2440/2972 | - |
dc.description.abstract | We investigated whether a polymorphism in the promoter region of the TNFα gene (−308 A/G) is associated with reduced weight loss in obese Australian subjects on an energy restricted diet. 189 healthy subjects and 91 subjects with type II diabetes were genotyped for the −308 Nco I polymorphism using PCR-RFLP techniques. A subset of these subjects (211 females and 45 males), were placed on a 30% energy restricted diet (6200 kJ) for 12 weeks. Subjects were assessed every 2 weeks and changes in body weight, waist circumference and BMI were used as determinants of weight loss. Fasting plasma was analysed for glucose, insulin, lipids and free fatty acids. 64% of subjects were GG homozygotes, 31% were AG heterozygotes and 5% were AA homozygotes. There was no significant difference between the allele frequency in healthy subjects (0.21) and type 2 diabetic patients (0.24). The presence of the −308 A/G polymorphism did not significantly influence initial BMI, the amount of weight lost (GG, 8.1±0.65 kg, AG, 6.9±0.77 kg, AA, 7.6±0.12 kg), waist circumference or any metabolic variable. The AA variant at position −308 in the promoter region of the TNFα gene does not influence the amount of weight lost in overweight and obese men and women on a 30% energy restricted diet. | - |
dc.description.statementofresponsibility | Alison M. Morris, Leonie K. Heilbronn, Manny Noakes, Karen L. Kind and Peter M. Clifton | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/505949/description#description | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ireland Ltd | - |
dc.source.uri | http://dx.doi.org/10.1016/j.diabres.2003.08.002 | - |
dc.subject | Tumour necrosis factor alpha polymorphism | - |
dc.subject | obesity | - |
dc.subject | weight loss | - |
dc.title | -308 Nco I polymorphism of tumour necrosis factor a in overweight caucasians | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.diabres.2003.08.002 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Heilbronn, L. [0000-0003-2106-7303] | - |
dc.identifier.orcid | Clifton, P. [0000-0002-6411-626X] | - |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 6 Molecular and Biomedical Science publications |
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