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https://hdl.handle.net/2440/32858
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Type: | Journal article |
Title: | Ketanserin in women with chronic hypertension and underlying thrombophilia |
Author: | Banga, F. Bolte, A. Dekker, G. van Geijn, H. |
Citation: | Obstetrics and Gynecology, 2004; 103(5):1084-1087 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2004 |
ISSN: | 0029-7844 1873-233X |
Statement of Responsibility: | Franyke R.Banga, Antoinette C. Bolte, Gustaaf A. Dekker, Herman P. van Geijn |
Abstract: | BACKGROUND: Pregnant women with chronic hypertension and thrombophilia have an increased risk for preeclampsia and/or intrauterine growth restriction (IUGR). Ketanserin lowers blood pressure and inhibits serotonin-induced platelet aggregation. CASES: A 38-year-old woman with chronic hypertension had a first pregnancy with severe hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. A second pregnancy with prophylactic oral ketanserin and low-dose aspirin was uneventful. The third pregnancy without oral ketanserin was again complicated by severe superimposed preeclampsia and IUGR. During this pregnancy a prothrombin mutation was found. A 37-year-old woman with chronic hypertension developed severe early-onset superimposed preeclampsia in her first pregnancy. In the 3 consecutive pregnancies, she was treated with low-molecular-weight heparin because of a factor XII deficiency. Only the pregnancy with the use of prophylactic oral ketanserin was uncomplicated. CONCLUSION: Clinical trials are warranted to analyze the role of oral ketanserin in preventing preeclampsia and IUGR. |
Keywords: | Humans Pregnancy Complications Fetal Growth Retardation HELLP Syndrome Pre-Eclampsia Hypertension Thrombophilia Ketanserin Antihypertensive Agents Pregnancy Adult Female |
Rights: | © 2004 The American College of Obstetricians and Gynecologists |
DOI: | 10.1097/01.AOG.0000117085.65925.f2 |
Description (link): | http://journals.lww.com/greenjournal/Abstract/2004/05001/Ketanserin_in_Women_With_Chronic_Hypertension_and.20.aspx |
Published version: | http://ovidsp.ovid.com.proxy.library.adelaide.edu.au/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006250-200405001-00020&LSLINK=80&D=ovft |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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