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https://hdl.handle.net/2440/34680
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dc.contributor.author | Sanders, P. | - |
dc.contributor.author | Hocini, M. | - |
dc.contributor.author | Jais, P. | - |
dc.contributor.author | Hsu, L. | - |
dc.contributor.author | Takahashi, Y. | - |
dc.contributor.author | Rotter, M. | - |
dc.contributor.author | Scavee, C. | - |
dc.contributor.author | Pasquie, J. | - |
dc.contributor.author | Sacher, F. | - |
dc.contributor.author | Rostock, T. | - |
dc.contributor.author | Nalliah, C. | - |
dc.contributor.author | Clementy, J. | - |
dc.contributor.author | Haissaguerre, M. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Journal of the American College of Cardiology, 2005; 46(11):2088-2099 | - |
dc.identifier.issn | 0735-1097 | - |
dc.identifier.issn | 1558-3597 | - |
dc.identifier.uri | http://hdl.handle.net/2440/34680 | - |
dc.description | © 2005 by the American College of Cardiology Foundation | - |
dc.description.abstract | <h4>Objectives</h4>The goal of this study was to characterize the origin of focal atrial tachycardias (AT).<h4>Background</h4>Focal ATs originate from a small area and spread centrifugally; however, activation at the AT origin has not been characterized.<h4>Methods</h4>Twenty patients with AT having failed prior ablation or occurring after atrial fibrillation ablation were studied. After excluding macro-re-entry, AT was mapped using a 20-pole catheter (five radiating spines; diameter 3.5 cm), performing vector mapping to identify the earliest activity followed by high-density mapping at the AT origin. Localized re-entry was considered if >85% of the tachycardia cycle length (CL) was observed within the mapping field and was confirmed by entrainment.<h4>Results</h4>A total of 27 ATs were mapped to the pulmonary vein ostia (n = 5), and left (n = 16) and right atria (n = 6). A localized focus was evidenced at the site of origin in 19 ATs (70%), whereas in 8 (30%), localized re-entry was evidenced by 95.2 +/- 4.5% of the tachycardia CL recorded within the mapping field and entrainment showed a post-pacing interval <20 ms longer than tachycardia CL (6 of 6 tested). Localized re-entry had a shorter CL (p = 0.009), slowed conduction at its origin (fractionated potential 115 +/- 19 ms vs. 64 +/- 22 ms, representing 49 +/- 10% and 20 +/- 10% of tachycardia CL, respectively; p < 0.0001), and were more often contiguous with regions of electrical silence or conduction abnormalities (88% vs. 32%; p = 0.01). In addition, mapping documented varying degrees of intra-atrial conduction block, preferential conduction (n = 5), and rapid bursts of myocardial activity (n = 1). At 11 +/- 7 months, none have had recurrence of AT.<h4>Conclusions</h4>High-density multielectrode mapping can be used to perform vector mapping to localize complex AT. It provides novel insight into the mechanisms of focal AT, distinguishing focal AT from localized re-entry. | - |
dc.description.statementofresponsibility | Prashanthan Sanders, Mélèze Hocini, Pierre Jaïs, Li-Fern Hsu, Yoshihide Takahashi, Martin Rotter, Christophe Scavée, Jean-Luc Pasquié, Fréderic Sacher, Thomas Rostock, Chrishan J. Nalliah, Jacques Clémenty, Michel Haïssaguerre | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science Inc | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jacc.2005.08.044 | - |
dc.subject | Heart Atria | - |
dc.subject | Humans | - |
dc.subject | Tachycardia | - |
dc.subject | Electrocardiography | - |
dc.subject | Electrophysiologic Techniques, Cardiac | - |
dc.subject | Catheter Ablation | - |
dc.subject | Equipment Design | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Cardiac Catheterization | - |
dc.title | Characterization of focal atrial tachycardia using high-density mapping | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jacc.2005.08.044 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Sanders, P. [0000-0003-3803-8429] | - |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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