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https://hdl.handle.net/2440/34827
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Type: | Journal article |
Title: | Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation |
Author: | Lando, D. Gorman, J. Whitelaw, M. Peet, D. |
Citation: | The Federation of European Biochemical Societies (FEBS) Journal, 2003; 270(5):781-790 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2003 |
ISSN: | 1742-464X 1432-1033 |
Organisation: | Centre for the Molecular Genetics of Development |
Statement of Responsibility: | David Lando, Jeffrey J. Gorman, Murray L. Whitelaw and Daniel J. Peet |
Abstract: | To sustain life mammals have an absolute and continual requirement for oxygen, which is necessary to produce energy for normal cell survival and growth. Hence, maintaining oxygen homeostasis is a critical requirement and mammals have evolved a wide range of cellular and physiological responses to adapt to changes in oxygen availability. In the past few years it has become evident that the transcriptional protein complex hypoxia-inducible factor (HIF) is a key regulator of these processes. In this review we will focus on the way oxygen availability regulates HIF proteins and in particular we will discuss the way oxygen-dependent hydroxylation of specific amino acid residues has been demonstrated to regulate HIF function at the level of both protein stability and transcriptional potency. |
Keywords: | oxygen sensing hypoxia hydroxylation transcriptional regulation hypoxia-inducible factor (HIF) |
Description: | European Journal of Biochemistry changed its name to FEBS Journal in January 2005 |
DOI: | 10.1046/j.1432-1033.2003.03445.x |
Published version: | http://www3.interscience.wiley.com/journal/118830274/abstract |
Appears in Collections: | Aurora harvest 6 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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