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https://hdl.handle.net/2440/34889
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Type: | Journal article |
Title: | α-Ketoester-based photobiological switches: synthesis, peptide chain extension and assay against α-chymotrypsin |
Other Titles: | alpha-Ketoester-based photobiological switches: synthesis, peptide chain extension and assay against alpha-chymotrypsin |
Author: | Harvey, A. Abell, A. |
Citation: | Bioorganic and Medicinal Chemistry Letters, 2001; 11(18):2441-2444 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2001 |
ISSN: | 0960-894X |
Statement of Responsibility: | Andrew J. Harvey and Andrew D. Abell |
Abstract: | The design, synthesis, photoisomerism and biological testing of two peptide-based photoswitchable inhibitors of α-chymotrypsin are presented. The use of a dipeptide recognition sequence gave a ‘slow-tight binding’ inhibitor, while the introduction of a carbamate linker to the azobenzene gave a modest enhancement in photoswitching of enzyme activity for the photostationary state enriched in the (Z)-isomer over the (E)-isomer. |
Description: | Copyright © 2001 Elsevier Science Ltd. All rights reserved. |
DOI: | 10.1016/S0960-894X(01)00464-4 |
Description (link): | http://www.sciencedirect.com/science/journal/0960894X |
Published version: | http://dx.doi.org/10.1016/s0960-894x(01)00464-4 |
Appears in Collections: | Aurora harvest Chemistry publications |
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