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https://hdl.handle.net/2440/38009
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DC Field | Value | Language |
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dc.contributor.author | Schmidt, O. | - |
dc.contributor.author | Rahman, M. | - |
dc.contributor.author | Ma, G. | - |
dc.contributor.author | Theopold, U. | - |
dc.contributor.author | Sun, Y. | - |
dc.contributor.author | Sarjan, M. | - |
dc.contributor.author | Fabbri, M. | - |
dc.contributor.author | Roberts, H. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Invertebrate Survival Journal, 2005; 2(2):82-90 | - |
dc.identifier.issn | 1824-307X | - |
dc.identifier.issn | 1824-307X | - |
dc.identifier.uri | http://hdl.handle.net/2440/38009 | - |
dc.description.abstract | Antimicrobial peptides and pore-forming toxins are important effectors in innate immune defence reactions. But their mode of action, comprising the insertion into cholesterol-containing membranes is not known. Here we explore the mechanical implications of pore-formation by extracellular protein assemblies that drive cellular uptake reactions by leverage-mediated (LM) processes, where oligomeric adhesion molecules bent membrane-receptors around ‘hinge’-like lipophorin particles. The interactions of antimicrobial peptides, pore-forming toxins and biologically active proteins with LMassemblies provide a new paradigm for the configurational specificity and sterical selectivity of biologically active peptides. | - |
dc.language.iso | en | - |
dc.publisher | Universita degli Studi di Modena e Reggio Emilia | - |
dc.source.uri | http://www.isj.unimo.it/articoli/ISJ104.pdf | - |
dc.subject | Antimicrobial peptides | - |
dc.subject | pore-forming toxins | - |
dc.subject | peptide hormones | - |
dc.subject | endocytosis | - |
dc.subject | lipophorin | - |
dc.subject | cholesterol | - |
dc.subject | lipid rafts | - |
dc.subject | channel formation | - |
dc.subject | lectins | - |
dc.title | Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis) | - |
dc.type | Journal article | - |
pubs.publication-status | Published | - |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 6 |
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