Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/39104
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Coronary artery disease: Pathogenesis and acute coronary syndromes |
Author: | Worthley, S. Osende, J. Helft, G. Badimon, J. Fuster, V. |
Citation: | Mount Sinai Journal of Medicine, 2001; 68(3):167-181 |
Publisher: | Mount Sinai Hospital |
Issue Date: | 2001 |
ISSN: | 0027-2507 1931-7581 |
Statement of Responsibility: | Stephen G. Worthley, Julio I. Osende, Gérard Helft, Juan J. Badimon, and Valentin Fuster |
Abstract: | Atherosclerotic diseases and their thrombotic complications remain the leading causes of mortality and morbidity in Western society. In the United States, cardiovascular disease is responsible for one in every 2.4 (41.4%) deaths and is the leading single cause of mortality. Furthermore, the presence of atherosclerotic disease (defined as thickening of the arterial wall through the accumulation of lipids, macrophages, T-lymphocytes, smooth muscle cells, extracellular matrix, calcium and necrotic debris) is more prevalent, but by itself rarely fatal. The crucial, final common process for the conversion of a nonocclusive, often clinically silent atherosclerotic lesion to a potentially fatal condition is often plaque disruption. The mortality associated with atherosclerotic disease relates to the acute coronary syndromes, including acute myocardial infarction, unstable angina pectoris and sudden cardiac death. Substantial clinical, experimental and postmortem evidence demonstrates the central role that a superimposed acute thrombosis on a disrupted atherosclerotic plaque plays in the onset of acute coronary syndromes. Therefore, therapeutic approaches to date have focused on reducing such thrombotic complications of atherosclerotic plaques (i.e., antiplatelet, anticoagulant and thrombolytic therapies) to reduce the resulting morbidity and mortality. In this review, we will focus on the current theories of atherogenesis and how they impact on our understanding of acute coronary syndromes. |
Keywords: | atherogenesis atherosclerosis platelets platelet aggregation thrombogenicity thrombosis acute coronary syndrome plaque formation plaque disruption hemodynamics Q-wave myocardial infarction rheology collateral circulation risk factors |
Rights: | © 2001 The Mount Sinai Journal of Medicine |
DOI: | 10.1056/NEJM199201303260506 |
Description (link): | http://www.ncbi.nlm.nih.gov/pubmed/11373689 |
Published version: | http://dx.doi.org/10.1056/nejm199201303260506 |
Appears in Collections: | Aurora harvest 6 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.