Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/41428
Type: | Conference paper |
Title: | Inhibition of neurogenic inflammation attenuates the inflammatory response following traumatic brain injury in rats |
Author: | Reardon, K. Heath, D. Nimmo, A. Vink, R. Whitfield, K. |
Citation: | 7th International Neurotrauma Symposium, Adelaide, Australia, 12-16 September, 2004: pp.115-118 |
Publisher: | Medimond International Proceedings |
Publisher Place: | Bologna, Italy |
Issue Date: | 2004 |
ISBN: | 88-7587-082-9 9788875870829 |
Conference Name: | International Neurotrauma Symposium (7th : 2004 : Adelaide, S. Aust.) |
Statement of Responsibility: | K. Reardon, D. Heath, A. Nimmo, R. Vink and K. Whitfield |
Abstract: | A profound inflammatory response is initiated following traumatic brain injury (TBI). It has been proposed that serum IL-6 levels may serve as a marker for the severity of the injury. Using the rat impact-acceleration model of TBI, the study examined whether drugs which are able to inhibit neurogenic inflammation (capsaicin, NK1 antagonist), might influence the post-traumatic inflammatory response. In non-treated animals, TBI resulted in a significant increase in serum IL-6 levels. However, in animals pre-treated with capsaicin prior to injury, or treated with an NK1 antagonist following injury, this rise in IL-6 levels was not observed. We conclude that the inhibition of neurogenic inflammation may attenuate the inflammatory reaction associated with TBI, and help improve outcome. |
Description: | © 2004 by MEDIMOND The document attached has been archived with permission from the Medimond International Proceedings Division. An external link to the publisher’s web site is included. |
Description (link): | http://www.medimond.com/proceedings/moreinfo/20040912.htm |
Appears in Collections: | Aurora harvest 6 Pathology publications |
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