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https://hdl.handle.net/2440/43820
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dc.contributor.author | Pilichiewicz, A. | - |
dc.contributor.author | Chaikomin, R. | - |
dc.contributor.author | Brennan, I. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Rayner, C. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Smout, A. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | American Journal of Physiology: Endocrinology and Metabolism, 2007; 293(3):E743-E753 | - |
dc.identifier.issn | 0193-1849 | - |
dc.identifier.issn | 1522-1555 | - |
dc.identifier.uri | http://hdl.handle.net/2440/43820 | - |
dc.description | Copyright © 2007 by the American Physiological Society. | - |
dc.description.abstract | Gastric emptying is a major determinant of glycemia, gastrointestinal hormone release, and appetite. We determined the effects of different intraduodenal glucose loads on glycemia, insulinemia, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and cholecystokinin (CCK), antropyloroduodenal motility, and energy intake in healthy subjects. Blood glucose, plasma hormone, and antropyloroduodenal motor responses to 120-min intraduodenal infusions of glucose at 1) 1 ("G1"), 2) 2 ("G2"), and 3) 4 ("G4") kcal/min or of 4) saline ("control") were measured in 10 healthy males in double-blind, randomized fashion. Immediately after each infusion, energy intake at a buffet meal was quantified. Blood glucose rose in response to all glucose infusions (P < 0.05 vs. control), with the effect of G4 and G2 being greater than that of G1 (P < 0.05) but with no difference between G2 and G4. The rises in insulin, GLP-1, GIP, and CCK were related to the glucose load (r > 0.82, P < 0.05). All glucose infusions suppressed antral (P < 0.05), but only G4 decreased duodenal, pressure waves (P < 0.01), resulted in a sustained stimulation of basal pyloric pressure (P < 0.01), and decreased energy intake (P < 0.05). In conclusion, variations in duodenal glucose loads have differential effects on blood glucose, plasma insulin, GLP-1, GIP and CCK, antropyloroduodenal motility, and energy intake in healthy subjects. These observations have implications for strategies to minimize postprandial glycemic excursions in type 2 diabetes. | - |
dc.description.statementofresponsibility | Amelia N. Pilichiewicz, Reawika Chaikomin, Ixchel M. Brennan, Judith M. Wishart, Christopher K. Rayner, Karen L. Jones, Andre J. P. M. Smout, Michael Horowitz, and Christine Feinle-Bisset | - |
dc.language.iso | en | - |
dc.publisher | Amer Physiological Soc | - |
dc.source.uri | http://ajpendo.physiology.org/cgi/content/abstract/293/3/E743 | - |
dc.subject | Duodenum | - |
dc.subject | Pylorus | - |
dc.subject | Humans | - |
dc.subject | Insulin Resistance | - |
dc.subject | Hormones | - |
dc.subject | Insulin | - |
dc.subject | Glucose | - |
dc.subject | Energy Intake | - |
dc.subject | Gastrointestinal Motility | - |
dc.subject | Postprandial Period | - |
dc.subject | Adult | - |
dc.subject | Male | - |
dc.title | Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men | - |
dc.type | Journal article | - |
dc.provenance | First published July 3, 2007 | - |
dc.identifier.doi | 10.1152/ajpendo.00159.2007 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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