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https://hdl.handle.net/2440/46380
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Type: | Journal article |
Title: | Elevated levels of HER-2/neu and androgen receptor in clinically localized prostate cancer identifies metastatic potential |
Author: | Ricciardelli, C. Jackson, M. Choong, C. Stahl, J. Marshall, V. Horsfall, D. Tilley, W. |
Citation: | The Prostate, 2008; 68(8):830-838 |
Publisher: | Wiley-Liss |
Issue Date: | 2008 |
ISSN: | 0270-4137 1097-0045 |
Statement of Responsibility: | Ricciardelli C, Jackson M.W, Choong C.S, Stah J, Marshall V.R, Horsfall D.J and Tilley W.D. |
Abstract: | <h4>Background</h4>In this study, we investigated the expression of HER-2/neu and AR in clinically organ-confined prostate cancer to determine whether alterations in these signaling pathways contribute to the development of metastatic disease.<h4>Methods</h4>HER-2/neu and AR immunoreactivity were evaluated in archived prostatic tissues obtained from 53 men with clinically organ-confined disease who underwent radical prostatectomy. Associations between AR and HER-2/neu immunostaining and disease outcome were determined.<h4>Results</h4>Seventy percent (37/53) of tumors exhibited high levels of HER-2/neu immunostaining and 68% (36/53) of tumors had elevated AR levels. Patients with high levels of both HER-2/neu and AR had the highest rate of PSA failure (56%, 15/27) compared with no PSA failures amongst seven patients with low levels of both HER-2/neu and AR (log rank statistic 7.69, P = 0.021). Concurrent high levels of HER-2/neu and AR expression were significantly associated with high pathological stage (P = 0.027) and development of metastatic disease (P = 0.022).<h4>Conclusions</h4>These findings support the notion that both the HER-2/neu and AR signaling pathways may contribute to development of metastatic disease. The subset of prostate tumors with increased HER-2/neu and AR levels may benefit from treatment strategies that target both signaling pathways. |
Keywords: | Humans Prostatic Neoplasms Neoplasm Metastasis Neoplasm Recurrence, Local Prostate-Specific Antigen Receptor, erbB-2 Receptors, Androgen Prostatectomy Immunohistochemistry Aged Middle Aged Male |
DOI: | 10.1002/pros.20747 |
Published version: | http://dx.doi.org/10.1002/pros.20747 |
Appears in Collections: | Aurora harvest Medicine publications |
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