Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/46419
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Yun, Q. | - |
dc.contributor.author | Chen, T. | - |
dc.contributor.author | Zhang, G. | - |
dc.contributor.author | Bi, J. | - |
dc.contributor.author | Ma, G. | - |
dc.contributor.author | Su, Z. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Biotechnology Letters, 2005; 27(3):213-217 | - |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.issn | 1573-6776 | - |
dc.identifier.uri | http://hdl.handle.net/2440/46419 | - |
dc.description | The definitive version may be found at www.springerlink.com | - |
dc.description.abstract | A novel methoxypolyethylene glycol (mPEG) derivative, containing a reactive group of 1-methyl pyridinium toluene-4-sulfonate, was synthesized and characterized. The mPEG derivative was successfully conjugated with two proteins: recombinant human granulocyte-colony stimulating factor (rhG-CSF) and consensus interferon (C-IFN). Homogeneous mono-PEGylated proteins were obtained which were identified by high performance size-exclusion chromatography and MALDI-TOF mass spectrometry. The biological activities of the mono-PEGylated rhG-CSF and the mono-PEGylated C-IFN were maintained at 90% and 88%, respectively. | - |
dc.description.statementofresponsibility | Qiang Yun, Ting Chen, Guifeng Zhang, Jingxiu Bi, Guanghui Ma and Zhiguo Su | - |
dc.language.iso | en | - |
dc.publisher | Kluwer Academic Publ | - |
dc.rights | © Springer | - |
dc.source.uri | http://www.springerlink.com/content/v7l8l16385257262/ | - |
dc.subject | consensus interferon | - |
dc.subject | granulocyte-colony stimulating factor | - |
dc.subject | PEGylation | - |
dc.subject | polyethylene glycol | - |
dc.title | Novel polyethylene glycol derivative suitable for the preparation of mono-PEGylated protein | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s10529-004-8354-7 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Bi, J. [0000-0001-7056-8572] | - |
Appears in Collections: | Aurora harvest Chemical Engineering publications |
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