Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/47801
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Type: | Journal article |
Title: | Animal cell division: a fellowship of the double ring? |
Author: | Saint, R. Somers, W. |
Citation: | Journal of Cell Science, 2003; 116(21):4277-4281 |
Publisher: | Company of Biologists Ltd |
Issue Date: | 2003 |
ISSN: | 0021-9533 1477-9137 |
Organisation: | Centre for the Molecular Genetics of Development |
Abstract: | Despite a century of research into the nature of animal cell division, a molecular explanation for the positioning of the actomyosin contractile ring has remained elusive. The discovery of a novel interaction between regulators of Rho family small GTPases has revealed a link between the mitotic microtubules and the contractile ring during the later stages of mitosis. The properties of the interacting Rho regulators suggest a molecular model for the positioning and initiation of contractile ring furrowing in animal cells. In this ‘double ring’ model, centralspindlin complexes, localized by the action of their kinesin-like protein component, position and activate a cortical equatorial ring of Rho GTPase exchange factors. The resulting ring of activated Rho would then trigger a cascade of events leading to formation and constriction of the contractile ring. |
Keywords: | Cytokinesis Rho GTPase PBL/Ect2 RhoGEF Contractile ring PAV-KLP/MKLP1 Central spindle Microtubules |
DOI: | 10.1242/jcs.00816 |
Published version: | http://dx.doi.org/10.1242/jcs.00816 |
Appears in Collections: | Aurora harvest 6 Centre for the Molecular Genetics of Development publications |
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hdl_47801.pdf | 117.95 kB | Publisher's PDF | View/Open |
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