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https://hdl.handle.net/2440/48537
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Type: | Journal article |
Title: | Switching in of Ac-(Ala)₁₀-NHMe at a solid surface |
Other Titles: | Switching in of Ac-(Ala)(10)-NHMe at a solid surface |
Author: | Biggs, M. Mijajlovic, M. |
Citation: | Nanomedicine: Nanotechnology, Biology and Medicine, 2008; 4(3):262-265 |
Publisher: | Elsevier Inc |
Issue Date: | 2008 |
ISSN: | 1549-9634 1549-9642 |
Statement of Responsibility: | Mark J. Biggs, Milan Mijajlovic |
Abstract: | Using molecular simulation, we show how Ac-(Ala)(10)-NHMe adsorbed on a solid surface switches between three conformations at distinct surface energies. The first switch is from an alpha-helix to a 3.1(10)-helix. The second involves further stretching to a 2(7)-helix. This switching has several potential applications including memory in molecular computers to motility elements in nanotechnology, and could be relevant to biological activity of proteins near solid surfaces (e.g., nano and aerosol particles) and disease processes induced by such interactions. |
Keywords: | Biomaterials Molecular switches Peptide Protein structures Protein function and disease |
Rights: | © 2008 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.nano.2008.03.008 |
Published version: | http://dx.doi.org/10.1016/j.nano.2008.03.008 |
Appears in Collections: | Aurora harvest 6 Chemical Engineering publications Environment Institute publications |
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