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https://hdl.handle.net/2440/50906
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dc.contributor.author | Pilichiewicz, A. | - |
dc.contributor.author | Feltrin, K. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Holtmann, G. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Talley, N. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | American Journal of Gastroenterology, 2008; 103(10):2613-2623 | - |
dc.identifier.issn | 0002-9270 | - |
dc.identifier.issn | 1572-0241 | - |
dc.identifier.uri | http://hdl.handle.net/2440/50906 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: In patients with functional dyspepsia (FD), symptoms are frequently triggered, or exacerbated, by fatty foods. We hypothesized that in FD patients, a high-fat (high-FAT) meal would induce more symptoms than a high-carbohydrate (high-CHO) meal, associated with an altered secretion of cholecystokinin (CCK), peptide-YY (PYY), and ghrelin and an increased antral size, when compared to healthy subjects (HS). METHODS: FD symptoms, appetite perceptions, plasma hormones, and antral area were measured in 8 FD patients and 8 HS on three separate days after the ingestion of high-CHO or high-FAT (500 kcal/400 g) meals, or a low-nutrient control (180 kcal/400 g); the energy intake was quantified 60 min later. RESULTS: Nausea (P < 0.01) and pain (P= 0.05) were greater in FD after the high-FAT, when compared to high-CHO and control meals and in HS. Discomfort was greater after all meals in FD when compared to HS (P < 0.05). Fasting CCK and stimulation of CCK by the high-FAT (P < 0.01) meal were greater in FD, while fasting and postprandial PYY were lower (P < 0.001) in FD than in HS, with no differences in fasting, or postprandial, plasma ghrelin between FD and HS. Fasting antral area was greater in FD (P < 0.05), with no differences postprandially between FD and HS. There were no differences in the energy intake between the two groups. CONCLUSIONS: In FD patients: (a) a high-FAT meal induces more symptoms than an isocaloric high-CHO meal, and (b) fasting and postprandial plasma CCK concentrations are greater and PYY concentrations are less. Our findings have important implications for the development of diet-based therapies for the treatment of FD. | - |
dc.description.statementofresponsibility | Amelia N Pilichiewicz, Kate L. Feltrin, Michael Horowitz, Gerald Holtmann, Judith M. Wishart, Karen L. Jones, Nicholas J. Talley and Christine Feinle-Bisset | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.rights | © 2009 The American College of Gastroenterology | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1572-0241.2008.02041.x | - |
dc.subject | Humans | - |
dc.subject | Disease Progression | - |
dc.subject | Dyspepsia | - |
dc.subject | Cholecystokinin | - |
dc.subject | Peptide YY | - |
dc.subject | Dietary Carbohydrates | - |
dc.subject | Dietary Fats | - |
dc.subject | Prognosis | - |
dc.subject | Fasting | - |
dc.subject | Follow-Up Studies | - |
dc.subject | Postprandial Period | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Surveys and Questionnaires | - |
dc.title | Functional dyspepsia is associated with a greater symptomatic response to fat but not carbohydrate, increased fasting and postprandial CCK, and diminished PYY | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1572-0241.2008.02041.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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