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https://hdl.handle.net/2440/51294
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Type: | Journal article |
Title: | Variolins and related alkaloids |
Author: | Walker, S. Carter, E. Huff, B. Morris, J. |
Citation: | Chemical Reviews, 2009; 109(7):3080-3098 |
Publisher: | Amer Chemical Soc |
Issue Date: | 2009 |
ISSN: | 0009-2665 1520-6890 |
Statement of Responsibility: | Scott R. Walker, Erin J. Carter, Belinda C. Huff, and Jonathan C. Morris |
Abstract: | Variolin B, a novel marine alkaloid that was isolated from the rare and difficult-to-access, Antarctic sponge Kirkpatrickia varialosa by the group of Blunt and Munro, is a cyclin-dependent kinases (CDK). despite their modest size, the variolins presented a challenge in their structural elucidation because of the presence of several ring-nitrogen atoms and relatively few hydrogen atoms in the structure. Hernandez Franco and Palermo reported the isolation of five 3-(2-aminopyrimidine)indoles, which were named meridianins A-E from the tunicate Apidium meridianum which has been collected at a depth of 100 m near the South Georgia Islands. The aplicyanin family was isolated from the Antarctic tunicate Aplidium cyaneum and consists of six variants on a core 3-(tetrahydropyrimidyl) indole structure. Kuhn and co-workers used their modeling software SLIDE to identify variolin B as the top candidate for the inhibition of the AsnRS found in Brugia malayi. |
Keywords: | Aza Compounds Indole Alkaloids Pyrimidines Cyclin-Dependent Kinases Antineoplastic Agents Bridged Bicyclo Compounds, Heterocyclic |
DOI: | 10.1021/cr900032s |
Published version: | http://dx.doi.org/10.1021/cr900032s |
Appears in Collections: | Aurora harvest 5 Chemistry and Physics publications |
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