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https://hdl.handle.net/2440/54034
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Type: | Journal article |
Title: | Effect of dietary n-3 polyunsaturated fatty acids on brain lipid fatty acid composition, learning ability, and memory of senescence-accelerated mouse |
Author: | Petursdottir, A. Farr, S. Morley, J. Banks, W. Skuladottir, G. |
Citation: | Journal of Gerontology Series A: Biological Sciences and Medical Sciences, 2008; 63(11):1153-1160 |
Publisher: | Gerontological Society of America |
Issue Date: | 2008 |
ISSN: | 1079-5006 1758-535X |
Statement of Responsibility: | Anna L. Petursdottir, Susan A. Farr, John E. Morley, William A. Banks and Gudrun V. Skuladottir |
Abstract: | Animal studies have shown that a deficiency in brain of the n-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with memory loss and diminished cognitive function. The senescence-accelerated prone 8 (SAMP8) mouse develops impairments in learning and memory at 8–12 months of age. The effect of diet supplemented with n-3 PUFA on brain phospholipid DHA status, learning, and memory ability in aged SAMP8 mice was investigated. At the age of 10 months, SAMP8 mice were fed either a low-DHA or a high-DHA diet for 8 weeks. In comparison to SAMP8 mice fed the low-DHA diet, those fed a high-DHA diet had improved acquisition and retention in a T-maze foot shock avoidance test and a higher proportion of DHA in hippocampal and amygdala phospholipids. This study demonstrates that, in mature animals, DHA is incorporated into brain phospholipids and that dietary n-3 PUFA is associated with delay in cognitive decline. |
Keywords: | Alzheimer's disease n-3 Polyunsaturated fatty acids Docosahexaenoic acid Hippocampus Memory |
Rights: | Copyright 2008 by The Gerontological Society of America |
DOI: | 10.1093/gerona/63.11.1153 |
Published version: | http://biomed.gerontologyjournals.org/cgi/content/abstract/63/11/1153 |
Appears in Collections: | Aurora harvest Medicine publications |
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