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https://hdl.handle.net/2440/54767
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dc.contributor.author | Kuo, P. | - |
dc.contributor.author | Gentilcore, D. | - |
dc.contributor.author | Nair, N. | - |
dc.contributor.author | Stevens, J. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Lange, K. | - |
dc.contributor.author | Gilja, O. | - |
dc.contributor.author | Hausken, T. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Rayner, C. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Neurogastroenterology and Motility, 2009; 21(11):1175-1183 | - |
dc.identifier.issn | 1350-1925 | - |
dc.identifier.issn | 1365-2982 | - |
dc.identifier.uri | http://hdl.handle.net/2440/54767 | - |
dc.description.abstract | The aim of this study was to determine whether the nitric oxide (NO) synthase inhibitor, N(g)-nitro-L-arginine-methyl-ester (L-NAME), reverses the effects of acute hyperglycaemia on gastric emptying and antropyloroduodenal (APD) motility. The study had a four-way randomized crossover (hyperglycaemia vs euglycaemia; L-NAME vs placebo) design in a clinical laboratory setting. Seven healthy volunteers [four males; age 30.3 +/- 3.8 years; body mass index (BMI) 23.6 +/- 1.2 kg m(-2)] were the study subjects. After positioning a transnasal manometry catheter across the pylorus, the blood glucose concentration was maintained at either 15 or 5 mmol L(-1) using a glucose/insulin clamp. An intravenous infusion of L-NAME (180 microg kg(-1 )h(-1)) or placebo (0.9% saline) was commenced (T = -30 min) and continued for 150 min. At T = -2 min, subjects ingested a drink containing 50 g of glucose made up to 300 mL with water. Gastric emptying was measured using 3D ultrasound, and APD motility using manometry. Hyperglycaemia slowed gastric emptying (P < 0.05), and this effect was abolished by L-NAME. L-NAME had no effect on gastric emptying during euglycaemia. Hyperglycaemia suppressed fasting antral motility [motility index: 3.9 +/- 0.8 (hyperglycaemia) vs 6.5 +/- 0.6 (euglycaemia); P < 0.01]; l-NAME suppressed postprandial antral motility [motility index: 3.6 +/- 0.2 (L-NAME) vs 5.1 +/- 0.2 (placebo); P < 0.001]. Postprandial basal pyloric pressure was higher during hyperglycaemia (P < 0.001), and lower after administration of L-NAME (P < 0.001). Slowing of gastric emptying induced by hyperglycaemia is mediated by NO, and may involve the modulation of tonic pyloric activity. | - |
dc.description.statementofresponsibility | Kuo P, Gentilcore D, Nair N, Stevens JE, Wishart JM, Lange K, Gilja OH, Hausken T, Horowitz M, Jones KL and Rayner CK | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1365-2982.2009.01321.x | - |
dc.subject | 3D ultrasound | - |
dc.subject | gastric emptying | - |
dc.subject | l-NAME | - |
dc.subject | motility | - |
dc.subject | nitric oxide | - |
dc.title | The nitric oxide synthase inhibitor, Ng-nitro-l-arginine-methyl-ester, attenuates the delay in gastric emptying induced by hyperglycaemia in healthy humans | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1365-2982.2009.01321.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lange, K. [0000-0003-3814-8513] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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