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https://hdl.handle.net/2440/55388
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Type: | Journal article |
Title: | Sex-Specific Differences in Peripheral Microvascular Blood Flow in Preterm Infants |
Author: | Stark, M. Clifton, V. Wright, I. |
Citation: | Pediatric Research, 2008; 63(4):415-419 |
Publisher: | Int Pediatric Research Foundation Inc |
Issue Date: | 2008 |
ISSN: | 0031-3998 1530-0447 |
Statement of Responsibility: | Michal J. Stark, Vicki L. Clifton, and Ian M. R. Wright |
Abstract: | Microvascular blood flow is related to physiologic instability in newborn preterm infants. We investigated sex-specific differences in basal microvascular blood flow and the ability of the microvasculature to respond to vasoactive stimuli following preterm birth. Ninety-six infants in two gestational age groups (24-28 and 29-36 wk) were studied on days 1-5 of life. Laser Doppler flowmetry was used to measure baseline microvascular blood flow and vasodilatation in response to acetylcholine and local warming. A significant interaction of gestational age and sex was observed for baseline flow at 24 h of age. In the 24-28 wk group, male infants had higher baseline flow than females. Male, but not female, infants born at 24-28 wk exhibited a significant relationship between baseline flow and vasodilatory response to acetylcholine at 24 h of age. By 120 h of age, both sexes exhibited similar responses. Infants born at 24-28 wk exhibited greater vasodilatation in response to local warming than those born at 29-36 wk at 24, 72, and 120 h of age. Sex-specific differences in microvascular blood flow and vasodilatory capacity in the immediate newborn period may affect the transitional circulation, contributing to excess of morbidity and mortality in preterm males. |
Keywords: | Microcirculation Humans Acetylcholine Vasodilator Agents Laser-Doppler Flowmetry Aging Sex Characteristics Regional Blood Flow Vasodilation Infant, Newborn Infant, Premature Female Male |
Description: | Copyright © 2008 International Pediatric Research Foundation, Inc. |
DOI: | 10.1203/01.pdr.0000304937.38669.63 |
Published version: | http://dx.doi.org/10.1203/01.pdr.0000304937.38669.63 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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