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https://hdl.handle.net/2440/56138
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Type: | Journal article |
Title: | Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial |
Author: | Holtmann, G. Adam, B. Haag, S. Collet, W. Grunewald, E. Windeck, T. |
Citation: | Alimentary Pharmacology and Therapeutics, 2003; 18(11-12):1099-1105 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2003 |
ISSN: | 0269-2813 1365-2036 |
Statement of Responsibility: | G. Holtmann, B. Adam, S. Haag, W. Collet, E. Grünewald & T. Windeck |
Abstract: | Background: This study aimed to assess the efficacy of artichoke leaf extract (ALE) in the treatment of patients with functional dyspepsia (FD). Methods: In a double-blind, randomized controlled trial (RCT), 247 patients with functional dyspepsia were recruited and treated with either a commercial ALE preparation (2 × 320 mg plant extract t.d.s.) or a placebo. The primary efficacy variable was the sum score of the patient's weekly rating of the overall change in dyspeptic symptoms (four-point scale). Secondary variables were the scores of each dyspeptic symptom and the quality of life (QOL) as assessed by the Nepean Dyspepsia Index (NDI). Results: Two hundred and forty-seven patients were enrolled, and data from 244 patients (129 active treatment, 115 placebo) were suitable for inclusion in the statistical analysis (intention-to-treat). The overall symptom improvement over the 6 weeks of treatment was significantly greater with ALE than with the placebo (8.3 ± 4.6, vs. 6.7 ± 4.8, P < 0.01). Similarly, patients treated with ALE showed significantly greater improvement in the global quality-of-life scores (NDI) compared with the placebo-treated patients (− 41.1 ± 47.6 vs. − 24.8 ± 35.6, P < 0.01). Conclusion: The ALE preparation tested was significantly better than the placebo in alleviating symptoms and improving the disease-specific quality of life in patients with functional dyspepsia. |
Description: | Article first published online: 20 NOV 2003 |
Rights: | © 2003 Blackwell Publishing Ltd. |
DOI: | 10.1046/j.1365-2036.2003.01767.x |
Published version: | http://dx.doi.org/10.1046/j.1365-2036.2003.01767.x |
Appears in Collections: | Aurora harvest Medicine publications |
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