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https://hdl.handle.net/2440/57085
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Type: | Journal article |
Title: | Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates |
Author: | Brady, J. Mannering, S. Kireta, S. Coates, P. Proietto, A. Cowan, P. d'Apice, A. Lew, A. |
Citation: | Immunology and Cell Biology, 2009; 87(5):413-418 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2009 |
ISSN: | 0818-9641 1440-1711 |
Statement of Responsibility: | Jamie L. Brady, Stuart I. Mannering, Svjetlana Kireta, Patrick T. Coates, Anna I. Proietto, Peter J. Cowan, Anthony J. F. D'Apice and Andrew M. Lew |
Abstract: | Using heterologous prime-boost (DNA immunization followed by immunization with transfected cells), we have generated depleting mouse anti-baboon CD2 monoclonal antibodies (mAb). These anti-CD2 mAb recognized a diverse range of primate CD2 from New World monkeys and Old World monkeys to humans and have potent immunosuppressive activity for human allo-MLR responses and anti-tetanus-toxoid recall responses. There was no upregulation of activation markers or release of cytokines when the mAb were incubated with human peripheral blood mononuclear cells. Using chimeric NOD-SCID IL2rγnull mice, the mAb were shown to deplete human and cynomolgus monkey T cells in vivo. These anti-CD2 mAb may therefore be important immunological tools in allo- and xenotransplantation. |
Keywords: | CD2 depleting DNA humanized mice monoclonal primate |
Description: | © 2009 Australasian Society for Immunology Inc. All rights reserved. |
DOI: | 10.1038/icb.2009.4 |
Published version: | http://dx.doi.org/10.1038/icb.2009.4 |
Appears in Collections: | Aurora harvest Medicine publications |
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