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https://hdl.handle.net/2440/58427
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Type: | Journal article |
Title: | Harmonization of molecular monitoring of CML therapy in Europe |
Author: | Muller, M. Cross, N. Erben, P. Schenk, T. Hanfstein, B. Ernst, T. Hehlmann, R. Branford, S. Saglio, G. Hochhaus, A. |
Citation: | Leukemia, 2009; 23(11):1957-1963 |
Publisher: | Nature Publishing Group |
Issue Date: | 2009 |
ISSN: | 0887-6924 1476-5551 |
Statement of Responsibility: | MC Muller, NCP Cross, P Erben, T Schenk, B Hanfstein, T Ernst, R Hehlmann, S Branford, G Saglio and A Hochhaus |
Abstract: | The high efficacy of the standard treatment of chronic myeloid leukemia (CML) with imatinib has prompted the need for accurate methods to monitor response at levels below the landmark of complete cytogenetic remission. Quantification of BCR–ABL transcripts has proven to be the most sensitive method available, and has shown prognostic impact with regard to progression-free survival. Until recently, variations in methods used to quantify BCR–ABL made it difficult to compare results between laboratories. An international program is now underway to harmonize the reporting of results according to an international scale (IS). In this review, we consider the background to the IS and the progress that has been made to date, with a particular focus on ongoing harmonization efforts in Europe. We provide recommendations for the propagation of the IS by national or regional laboratory networks. |
Keywords: | BCR–ABL chronic myeloid leukemia molecular monitoring international scale conversion factor EUTOS for CML |
Rights: | © 2009 Macmillan Publishers Limited. All rights reserved |
DOI: | 10.1038/leu.2009.168 |
Published version: | http://dx.doi.org/10.1038/leu.2009.168 |
Appears in Collections: | Aurora harvest Medicine publications |
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