Adelaide Research & Scholarship
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https://hdl.handle.net/2440/5993
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| Type: | Journal article |
| Title: | Actions of thienyl analogs of baclofen at GABAB receptors in rat neocortical slices |
| Other Titles: | Actions of thienyl analogs of baclofen at GABA(B) receptors in rat neocortical slices |
| Author: | Ong, J. Kerr, D. Vaccher, C. Berthelot, P. |
| Citation: | European Journal of Pharmacology, 1997; 329(2-3):133-136 |
| Publisher: | Elsevier BV |
| Issue Date: | 1997 |
| ISSN: | 0014-2999 1879-0712 |
| Statement of Responsibility: | Jennifer Ong, David I.B. Kerr, Claude Vaccher, Pascal Berthelot |
| Abstract: | In rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen and its thienyl analogs, 4-amino-3-(5-chlorothien-2-yl)-butanoic acid (5h), 4-amino-3-(5-methylthien-2-yl)-butanoic acid (5d), 4-amino-3-(5-bromothien-2-yl)-butanoic acid (5f) and 4-amino-3-(thien-3-yl)-butanoic acid (5j) dose-dependently suppressed the spontaneous discharges, antagonised by the GABA(B) receptor antagonist 2-hydroxysaclofen (200 microM). Their relative potencies were baclofen > 5h > 5d > 5f > 5j. These heterocyclic analogs may prove useful as GABA(B) receptor agonists in functional studies. |
| Keywords: | Baclofen: GABAB receptor agonist Thienyl baclofen analog 2-Hydroxysaclofen Neocortical slice, rat |
| Description: | Short communication |
| Rights: | © 1997 Elsevier Science B.V. |
| DOI: | 10.1016/S0014-2999(97)00185-4 |
| Published version: | http://dx.doi.org/10.1016/s0014-2999(97)00185-4 |
| Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 5 |
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