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https://hdl.handle.net/2440/63358
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dc.contributor.author | Little, T. | - |
dc.contributor.author | Gopinath, A. | - |
dc.contributor.author | Patel, E. | - |
dc.contributor.author | McGlone, A. | - |
dc.contributor.author | Lassman, D. | - |
dc.contributor.author | D'Amato, M. | - |
dc.contributor.author | McLaughlin, J. | - |
dc.contributor.author | Thompson, D. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Neurogastroenterology and Motility, 2010; 22(11):1183-e314 | - |
dc.identifier.issn | 1350-1925 | - |
dc.identifier.issn | 1365-2982 | - |
dc.identifier.uri | http://hdl.handle.net/2440/63358 | - |
dc.description.abstract | <h4>Background</h4>It is widely reported that hexose sugars slow gastric emptying (GE) via osmoreceptor stimulation but this remains uncertain. We evaluated the effects of a panel of hexoses of differing molecular structure, assessing the effects of osmolality, intra-individual reproducibility and the role of the CCK(1) receptor, in the regulation of GE by hexoses.<h4>Methods</h4>Thirty one healthy non-obese male and female subjects were studied in a series of protocols, using a (13) C-acetate breath test to evaluate GE of varying concentrations of glucose, galactose, fructose and tagatose, with water, NaCl and lactulose as controls. GE was further evaluated following the administration of a CCK(1) receptor antagonist. Three subjects underwent repeated studies to evaluate intra-individual reproducibility.<h4>Key results</h4>At 250 mOsmol, a hexose-specific effect was apparent: tagatose slowed GE more potently than water, glucose and fructose (P < 0.05). Fructose (P < 0.05) also slowed GE, but with substantial inter-, but not intra-, individual differences. As osmolality increased further the hexose-specific differences were lost. At 500 mOsmol, all hexoses slowed GE compared with water (P < 0.05), whereas lactulose and saline did not. The slowing of GE by hexose sugars appeared to be CCK(1) receptor-dependent.<h4>Conclusions & inferences</h4>The effects of hexose sugars on GE appear related to their molecular structure rather than osmolality per se, and are, at least in part, CCK(1) receptor-dependent. | - |
dc.description.statementofresponsibility | T. J. Little, A. Gopinath, E. Patel, A. Mcglone, D. J. Lassman, M. D’amato, J. T. Mclaughlin & D. G. Thompson | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.rights | © 2010 Blackwell Publishing Ltd | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1365-2982.2010.01552.x | - |
dc.subject | dexloxiglumide | - |
dc.subject | fructose | - |
dc.subject | galactose | - |
dc.subject | gastric emptying | - |
dc.subject | glucose | - |
dc.subject | tagatose. | - |
dc.title | Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK₁ receptor | - |
dc.title.alternative | Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK(1)receptor | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1365-2982.2010.01552.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Little, T. [0000-0001-9814-1036] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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