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https://hdl.handle.net/2440/64351
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Type: | Journal article |
Title: | Serum testosterone levels correlate with haemoglobin in middle-aged and older men |
Author: | Yeap, Bu B. Beilin, J. Knuiman, M. Olynyk, J. K. Bruce, D. G. Milward, E. A. |
Citation: | Internal Medicine Journal, 2009; 39(8):532-538 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2009 |
ISSN: | 1444-0903 |
School/Discipline: | School of Medicine |
Statement of Responsibility: | B. B. Yeap, J. Beilin, Z. Shi, M. W. Knuiman, J. K. Olynyk, D. G. Bruce and E. A. Milward |
Abstract: | Background: Lower testosterone levels are associated with anaemia in older men and women. The relation between testosterone and haemoglobin (Hb) in younger and middle-aged men is less well defined. The aim of the study was to examine the association between testosterone and Hb levels in men spanning middle to older ages. Methods: A cross-sectional analysis of 492 men aged 30.7–94.5 years from the Busselton Health Survey, Western Australia, was carried out. Haemoglobin (Hb), early-morning serum total testosterone and sex hormone-binding globulin (SHBG) were measured. Free testosterone was calculated using mass action equations. Results: Haemoglobin correlated to total and free testosterone concentrations (r= 0.13, P= 0.003 and r= 0.20, P < 0.001, respectively). Hb and SHBG were inversely correlated (r=−0.14, P= 0.001). Hb increased across lowest to highest quartiles of total testosterone (P= 0.02) and free testosterone (P < 0.001), but not SHBG. After adjusting for age, waist circumference, smoking status, alcohol consumption, renal function and ferritin, total testosterone was associated with Hb (β= 0.037, P= 0.003) as was free testosterone (β= 2.32, P < 0.001), whereas SHBG was not associated. Conclusion: Testosterone concentration modulates Hb levels in community-dwelling men across a wide age range. Further studies are needed to clarify implications of this association between testosterone and Hb in men. |
Keywords: | testosterone; free testosterone; haemoglobin; men. |
Rights: | © 2009 The Authors. Journal compilation © 2009 Royal Australasian College of Physicians |
DOI: | 10.1111/j.1445-5994.2008.01789.x |
Appears in Collections: | Medicine publications |
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