Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/66468
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Type: | Journal article |
Title: | Mesenchymal stem cell-mediated functional tooth regeneration in swine |
Author: | Sonoyama, W. Liu, Y. Fang, D. Yamaza, T. Seo, B. Zhang, C. Liu, H. Gronthos, S. Wang, C. Shi, S. Wang, S. |
Citation: | PLoS One, 2006; Dec 2006(1):e79- |
Publisher: | Public Library of Science |
Issue Date: | 2006 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Csete, M. |
Statement of Responsibility: | Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung-Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun-Yu Wang,Songtao Shi and Songlin Wang |
Abstract: | Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance. |
Keywords: | Mesenchymal Stem Cells Periodontal Ligament Tooth Dental Papilla Tooth Root Animals Swine Swine, Miniature Humans Mice Mesenchymal Stem Cell Transplantation Transplantation, Heterologous Regeneration Male |
Rights: | Copyright 2006 Sonoyama et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0000079 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0000079 |
Appears in Collections: | Aurora harvest Medicine publications |
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hdl_66468.pdf | Published version | 520.23 kB | Adobe PDF | View/Open |
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