Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/67530
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Comparing effects of a low-energy diet and a high-protein low-fat diet on sexual and endothelial function, urinary tract symptoms, and inflammation in obese diabetic men |
Author: | Khoo, J. Piantadosi, C. Duncan, R. Worthley, S. Jenkins, A. Noakes, M. Worthley, M. Lange, K. Wittert, G. |
Citation: | Journal of Sexual Medicine, 2011; 8(10):2868-2875 |
Publisher: | Blackwell Publishing Ltd. |
Issue Date: | 2011 |
ISSN: | 1743-6095 1743-6109 |
Statement of Responsibility: | Joan Khoo, Cynthia Piantadosi, Rae Duncan, Stephen G. Worthley, Alicia Jenkins, Manny Noakes, Matthew I. Worthley, Kylie Lange and Gary A. Wittert |
Abstract: | Introduction: Abdominal obesity and type 2 diabetes mellitus are associated with sexual and endothelial dysfunction, lower urinary tract symptoms (LUTS), and chronic systemic inflammation. Aim: To determine the effects of diet-induced weight loss and maintenance on sexual and endothelial function, LUTS, and inflammatory markers in obese diabetic men. Main Outcome Measures: Weight, waist circumference (WC), International Index of Erectile Function (IIEF-5) score, Sexual Desire Inventory (SDI) score, International Prostate Symptom Scale (IPSS) score, plasma fasting glucose and lipids, testosterone, sex hormone binding globulin (SHBG), inflammatory markers (high-sensitivity C-reactive protein [CRP] and interleukin-6 [IL-6]) and soluble E-selectin, and brachial artery flow-mediated dilatation (FMD) were measured at baseline, 8 weeks, and 52 weeks. Methods: Over 8 weeks, 31 abdominally obese (body mass index ≥ 30 kg/m2, WC ≥ 102 cm), type 2 diabetic men (mean age 59.7 years) received either a meal replacement-based low-calorie diet (LCD) ∼1,000 kcal/day (N = 19) or low-fat, high-protein, reduced-carbohydrate (HP) diet (N = 12) prescribed to decrease intake by ∼600 kcal/day. Subjects continued on, or were switched to, the HP diet for another 44 weeks. Results: At 8 weeks, weight and WC decreased by ∼10% and ∼5% with the LCD and HP diet, respectively. Both diets significantly improved plasma glucose, low-density lipoprotein (LDL), SHBG, IIEF-5, SDI and IPSS scores, and endothelial function (increased FMD, reduced soluble E-selectin). Erectile function, sexual desire, and urinary symptoms improved by a similar degree with both diets. CRP and IL-6 decreased with the HP diet. At 52 weeks, reductions in weight, WC, and CRP were maintained. IIEF-5, SDI, and IPSS scores improved further. Conclusions: Diet-induced weight loss induces rapid improvement of sexual, urinary, and endothelial function in obese diabetic men. A high-protein, carbohydrate-reduced, low-fat diet also reduces systemic inflammation and sustains these beneficial effects to 1 year. |
Keywords: | Erectile Dysfunction Urinary Tract Symptoms Obesity Diabetes Mellitus Sexual Function Endothelial Function |
Rights: | © 2011 International Society for Sexual Medicine |
DOI: | 10.1111/j.1743-6109.2011.02417.x |
Published version: | http://dx.doi.org/10.1111/j.1743-6109.2011.02417.x |
Appears in Collections: | Aurora harvest 5 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.